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  1. Special Precautions

    ... risky for people with PNH because it: Makes the complement system more active, which can cause hemolysis Increases the ...

    Topic section last updated 09/08/2017 - 12:34pm.

  2. Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

    ... diseases of excess activation of the alternative pathway of complement that are treated with eculizumab , a humanized monoclonal ... dysregulation and validating the modified Ham test as a system for preclinical drug development for atypical hemolytic uremic syndrome. ...

    Research Article last updated 11/28/2016 - 11:42am.

  3. Local TV covers AAMDSIF Peer Support Networker

    ...   PNH is an acquired rare disorder characterized the complement system destructing red blood cells to early. Red blood cells are missing ...

    Article last updated 11/28/2016 - 3:21pm.

  4. Youmna Kfoury, PhD

    ... libraries, we used the Clontech SMARTer Ultra low input RNA system which were then sequenced on Illumina Hiseq2000 instrument, resulting in ... the co-culture. In the case of up regulated genes we will complement our CRISPR based knock out with an over expression strategy. ...

    Grant Recipient last updated 12/15/2016 - 12:56pm.

  5. Interviews with the Experts: The Complement System in PNH

    ... association it has with PNH, what is the function of the complement system ? The complement system initially got that name because it ...

    Interview last updated 08/31/2016 - 8:39am.

  6. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... proteins involved in the regulation of the complement system renders PNH erythrocytes susceptible to complement-mediated lysis. Clinical manifestations include thromboembolic ...

    Research Article last updated 09/13/2016 - 1:53pm.

  7. Patrizia Ricci, PhD

    ... , and thrombosis . Recently, the availability of the complement inhibitor eculizumab has dramatically improved the treatment ... of a novel class of peptides which target the complement system at the level of C3, the key component of the complement.  The ...

    Grant Recipient last updated 09/14/2016 - 2:42pm.

  8. AK579 (COBALT)

    ... of the Investigator, would benefit from treatment with a complement C5 inhibitor  Aged 18 and above. No upper age limit Males ... Any other drug acting directly on the complement system is prohibited Chemotherapeutic agents within 3 months of ...

    Clinical Trial last updated 09/14/2016 - 10:39am.

  9. Interviews with the Experts: Hemolysis in PNH and Beyond

    ... within the blood vessels and is typically induced by the complement system , which is an integral part of the immune system. The purpose of the ...

    Interview last updated 08/31/2016 - 8:40am.

  10. Announcing AAMDSIF 2016 Research Awards

    ... attach to blood cells and protect them from destruction by complement, part our immune system. The result of this deficiency is a breakdown of red cells. If large ...

    Article last updated 06/09/2016 - 12:45pm.