Search | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. What is Flow Cytometry?

    ... cell are abnormal because they can be destroyed by the complement system , which is a component of our immune system. Using light ...

    Article last updated 10/10/2018 - 8:08am.

  2. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... (PNH) is a hematological disorder characterized by complement-mediated hemolytic anemia , thrombophilia, and bone ... extravascular hemolysis through the reticuloendothelial system. These findings have renewed the interest for the development of novel ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... (PNH) is a hematological disorder characterized by complement-mediated hemolytic anemia , thrombophilia, and bone ... extravascular hemolysis through the reticuloendothelial system. These findings have renewed the interest for the development of novel ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the lack of CD55 and ... opsonization of PNH erythrocytes in an established in vitro system. Both compounds demonstrated dose-dependent inhibition of hemolysis ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... The recent availability of eculizumab as the first complement inhibitor renewed the interest for complement-mediated damage in ... our understanding of different steps of the complement system in human diseases, as well as their modulation by current ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.

    ... to the pathogenesis of thrombosis in PNH. The terminal complement inhibitor, eculizumab, induced a significant and sustained decrease in the activation of both the plasma hemostatic system and the vascular endothelium, likely contributing to the protective ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... missing a protein that protects them from the body's immune system.  When red blood cells break apart, the hemoglobin inside is ... The Complement System The complement ...

    Page last updated 07/20/2018 - 5:15pm.

  8. Causes

    ... protect normal red blood cells from a part of your immune system called the complement system. These PNH cells are attacked and destroyed by the ...

    Topic section last updated 07/30/2018 - 2:12pm.

  9. Foundation Update - September 2016

    ... August webinars: •  Understanding the Complement System and the PNH Clone • Bone Marrow Transplantation for ...

    Article last updated 10/09/2017 - 2:50pm.

  10. Interviews with the Experts: The Complement System in PNH

    ... association it has with PNH, what is the function of the complement system ? The complement system initially got that name because it ...

    Interview last updated 08/31/2016 - 8:39am.