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  1. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... (PNH) is a hematological disorder characterized by complement-mediated hemolytic anemia , thrombophilia, and bone ... extravascular hemolysis through the reticuloendothelial system. These findings have renewed the interest for the development of novel ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... (PNH) is a hematological disorder characterized by complement-mediated hemolytic anemia , thrombophilia, and bone ... extravascular hemolysis through the reticuloendothelial system. These findings have renewed the interest for the development of novel ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the lack of CD55 and ... opsonization of PNH erythrocytes in an established in vitro system. Both compounds demonstrated dose-dependent inhibition of hemolysis ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... The recent availability of eculizumab as the first complement inhibitor renewed the interest for complement-mediated damage in ... our understanding of different steps of the complement system in human diseases, as well as their modulation by current ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.

    ... to the pathogenesis of thrombosis in PNH. The terminal complement inhibitor, eculizumab, induced a significant and sustained decrease in the activation of both the plasma hemostatic system and the vascular endothelium, likely contributing to the protective ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... missing a protein that protects them from the body's immune system.  When red blood cells break apart, the hemoglobin inside is ... The Complement System The complement ...

    Page last updated 07/20/2018 - 5:15pm.

  7. Causes

    ... protect normal red blood cells from a part of your immune system called the complement system. These PNH cells are attacked and destroyed by the ...

    Topic section last updated 07/30/2018 - 2:12pm.

  8. Foundation Update - September 2016

    ... August webinars: •  Understanding the Complement System and the PNH Clone • Bone Marrow Transplantation for ...

    Article last updated 10/09/2017 - 2:50pm.

  9. Interviews with the Experts: The Complement System in PNH

    ... association it has with PNH, what is the function of the complement system ? The complement system initially got that name because it ...

    Interview last updated 08/31/2016 - 8:39am.

  10. Small-molecule Factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

    ... diseases of excess activation of the alternative pathway of complement that are treated with eculizumab , a humanized monoclonal ... dysregulation and validating the modified Ham test as a system for preclinical drug development for atypical hemolytic uremic syndrome. ...

    Research Article last updated 11/28/2016 - 11:42am.