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  1. Insights into the Natural History of Paroxysmal Nocturnal Hemoglobinuria (PNH): Analysis of the Presenting Clinical, Haematological and Flow Cytometric Features of 705 Patients Leads to Improved Classification and Prediction of Clinical Course

    ... thrombosis (clots in blood vessels), and PNH clone size could be a powerful predictor of disease course. ...

    Research Review last updated 05/02/2016 - 9:20am.

  2. Nurse's Corner Summer 2015: Understanding the Etiology and Epidemiology of Myelodysplastic Syndromes

    ... is complex including interplay between a neoplastic clone and an inflammatory environment that early in the disease leads to ...

    Page last updated 07/27/2015 - 12:04pm.

  3. Dr. Vivienne Rebel reviews a recent study about p53 protein levels as a prognostic factor in MDS

    ... technology for identifying patients with a small clone of p53 mutated cells.  A disadvantage of IH is that it will not ...

    Research Review last updated 05/02/2016 - 9:17am.

  4. Clinical mutations associated with MDS and their importance for disease outcome

    ... mutated gene was found in all cells or only in a subset ( clone ); this stresses the importance of early detection of these gene ...

    Research Review last updated 05/02/2016 - 9:21am.

  5. Eltrombopag now an approved therapy for certain patients with severe aplastic anemia

    ... we excluded patients with active PNH, and/or with PNH clone size greater than 50 percent” said Dunbar.  “We were treating ... PNH clones smaller than 50 percent were treated, and their clone sizes tended to remain approximately the same.” Read more on our ...

    Page last updated 08/27/2014 - 2:19pm.

  6. PNH - Basics

    ... PNH red blood cells. Doctors also call them your PNH clone . The PNH red blood cells lack the shield of proteins that protect ...

    Topic section last updated 04/05/2016 - 4:02pm.

  7. North American Pediatric Aplastic Anemia Consortium Symposium

    ... precursors. However, in the absence of an MDS defining clone , such as monosomy 7 , these overlapping morphologies can make ...

    Page last updated 10/31/2013 - 4:06pm.

  8. Research Overview – Recent Past Progress and Projections for the Near-Term

    ... where it worked exceptionally well to suppress the clone and that this was a different mechanism altogether. We went back to ... targets in deletion 5q  allowed lenalimide to suppress the clone. Then when patients failed lenalidomide , we went back and studied ...

    Page last updated 01/14/2014 - 11:47am.

  9. Research Overview - Recent Past Progress and Projections for the Near-Term

    ... where it worked exceptionally well to suppress the clone . It was not until after its FDA approval, that we went back to the ... in deletion 5q that allowed lenalidomide to suppress the clone. Later, as patients failed lenalidomide, we went back and studied the ...

    Interview last updated 02/10/2014 - 9:40am.

  10. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... PNH ( paroxysmal nocturnal hemoglobinuria ) clone where tested Concurrent hormonal contraceptive use ...

    Clinical Trial last updated 04/29/2016 - 9:59am.