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  1. 2015 PNH Research Grant Guidelines

    ... stem cells Cause of the expansion of the PNH clone to clinically significant levels Genetic components of PNH ...

    Page last updated 08/25/2016 - 12:55pm.

  2. Phase 1 Study of TCP-ATRA for Adult Patients With AML and MDS (TCP-ATRA)

    ... (ATRA), which effectively differentiates the leukemic clone . Over 80% of APL patients can be cured with ATRA based therapies. For ...

    Clinical Trial last updated 04/29/2016 - 12:33pm.

  3. Prognostic value of telomere attrition in patients with aplastic anemia

    ... of a paroxysmal nocturnal hemoglobinuria (PNH) clone and reticulocyte count. Telomere length ...

    Research Review last updated 05/02/2016 - 9:25am.

  4. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... known PNH ( paroxysmal nocturnal hemoglobinuria ) clone         No concurrent hormonal oral contraceptive use   ... PNH ( paroxysmal nocturnal hemoglobinuria ) clone where tested   ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.

  5. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... half of aplastic anemia patients will develop the PNH clone . There are patients who fall more on one side of the spectrum or the ... that the use of cyclosporine in a patient with a large PNH clone will be more likely to have an effect on the kidney function-- unless ...

    Interview last updated 04/15/2015 - 9:39am.

  6. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... half of aplastic anemia patients will develop the PNH clone . There are patients who fall more on one side of the spectrum or the ... that the use of cyclosporine in a patient with a large PNH clone will be more likely to have an effect on the kidney function-- unless ...

    Interview last updated 05/14/2015 - 1:53pm.

  7. AA&MDSIF announces PNH grant awards

    ... that are responsible for selective advantage of PNH clone , and the immune response in T cells that attack the hematopoietic ...

    Article last updated 12/14/2016 - 11:41am.

  8. Shahram Kordasti, MD, PhD

    ... recruited 16 AA patients with a small to moderate PNH clone (with no cases of hemolytic PNH) and 8 age matched healthy volunteers ...

    Grant Recipient last updated 08/02/2016 - 3:35pm.

  9. Gene Mutations in Aplastic Anemia

    ... often formed abnormal clones gradually. The pace of clone development had no effect on blood counts or development of abnormal ...

    Research Review last updated 05/02/2016 - 9:15am.

  10. Ramon V. Tiu, MD

    ... aplastic anemia. None of the patients had a PNH clone at presentation. Improvements in blood counts were noted in three out ... cyclosporine . All four patients have not developed a PNH clone. In December 2011, Astellas Pharma US announced that the company has ...

    Grant Recipient last updated 10/30/2012 - 6:28pm.