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  1. Clone of Clone of Caring for Yourself

    Another side to effective patient behavior The key to becoming an empowered patient is simply deciding to make your life the best it can be. People with bone marrow failure and other chronic diseas...

    Page last updated 04/11/2016 - 12:34pm.

  2. Update on the diagnosis and management of paroxysmal nocturnal hemoglobinuria

    ... ; in addition, the extent to which the mutant stem cell clone expands in an individual patient determines the magnitude of the ...

    Research Article last updated 01/26/2017 - 11:03am.

  3. The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications

    ... therapeutics. Notably, the size of the TP53 mutant clone as measured by mutation allele burden is directly linked to ...

    Research Article last updated 01/26/2017 - 10:06am.

  4. Evaluation of efficacy of alemtuzumab in 5 patients with aplastic anemia and/or myelodysplastic neoplasm

    ... paroxysmal nocturnal hemoglobinuria (PNH) clone was detected before therapy. One responder relapsed after 15 months ... a subset of patients with MDS, even in the presence of a PNH clone. Bone Marrow Diseases:  ...

    Research Article last updated 11/01/2016 - 1:56pm.

  5. Technical advances in flow cytometry-based diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria

    ... resolution for paroxysmal nocturnal hemoglobinuria clone detection. Bone Marrow ...

    Research Article last updated 11/02/2016 - 10:42am.

  6. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... hemolytic anemia . PNH results from expansion of a clone of hematopoietic cells that, as a consequence of an inactivating ... proteins CD55 and CD59, the red cells arising from this clone are exquisitely sensitive to lysis by activated complement. Until a ...

    Research Article last updated 06/07/2016 - 10:56am.

  7. Clonal hematopoiesis in acquired aplastic anemia

    ... and PIGA mutations tend to disappear or show stable clone size and predict significantly better response to IST and clinical ... ASXL1, and other genes, which are likely to increase their clone size and associated with a faster progression to MDS/AML and predict an ...

    Research Article last updated 06/22/2016 - 10:18am.

  8. Fighting PNH While Helping PNH Patients

    ... and have been on it ever since. I have a significant PNH clone , but the drug is working well. So it’s under control for the most ...

    Patient Chronicle last updated 11/21/2016 - 12:47pm.

  9. Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion

    ... recurrent somatic mutations identified in the diseased clone on response to lenalidomide and the drug effects on clonal evolution ...

    Research Article last updated 04/29/2016 - 11:33am.

  10. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... than those transplanted with fewer blasts, the effect of clone size in patients with MDS without increased blast proportion is ...

    Research Article last updated 04/29/2016 - 10:22am.