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  1. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... of the HLA alleles, linking immune escape to clone emergence. Two patients had activating mutations in key signaling ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... PNH red blood cells. Doctors also call them your PNH clone . The PNH red blood cells lack the shield of proteins that protect ...

    Page last updated 07/20/2018 - 5:15pm.

  3. My Son's Aplastic Anemia

    ... this was indicative of any type of relapse. His PNH clone remained tiny and non- therapeutic as well. Jamie's counts were a bit ...

    Patient Chronicle last updated 04/26/2018 - 9:57am.

  4. Alina Dulau Florea, MD

    ... that were pre-determined. Our data show that the PNH clone size measured in BM mature neutrophils, monocytes and immature ... red cells correlates well with that in PB neutrophils.  The clone size among mature lymphocytes is smaller than in other white cells, most ...

    Grant Recipient last updated 01/12/2018 - 9:50am.

  5. Lenalidomide: Myelodysplastic syndromes with del(5q) and beyond

    ... In del(5q) MDS, lenalidomide suppresses the malignant clone to restore effective erythropoiesis by virtue of synthetic lethality, ...

    Research Article last updated 10/23/2017 - 10:58am.

  6. Foundation Update - September 2016

    ... Understanding the Complement System and the PNH Clone • Bone Marrow Transplantation for Pediatric Patients ...

    Article last updated 10/09/2017 - 2:50pm.

  7. Lenalidomide: Myelodysplastic syndromes with del(5q) and beyond

    ... In del(5q) MDS, lenalidomide suppresses the malignant clone to restore effective erythropoiesis by virtue of synthetic lethality, ...

    Research Article last updated 10/02/2017 - 9:54am.

  8. Foundation Update - August 2016

    ... Understanding the Complement System and the PNH Clone ; August 11, 2016 1:00 PM EDT • Bone Marrow ...

    Article last updated 10/09/2017 - 2:52pm.

  9. A retrospective study of paroxysmal nocturnal hemoglobinuria in pediatric and adolescent patients

    ... and absolute reticulocyte count and a bigger PNH clone size compared to PNH/BMD patients; also thrombotic events were ...

    Research Article last updated 05/02/2017 - 10:42am.

  10. Anastasios Karadimitris, MD, PhD

    ... with up to 50% of patients with IAA developing a PNH clone or bonafide PNH and a subgroup of patients with PNH evolving into ...

    Grant Recipient last updated 03/07/2017 - 9:50am.