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  1. Epigenetic alterations and microRNAs: New players in the pathogenesis of myelodysplastic syndromes.

    ... too. Myelodysplastic syndromes (MDS) are clone disorders of the hematopoietic stem cell with increased risk of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... bone marrow failure . The prevalence of the PNH clone (from <1-100% PNH granulocytes) is approximately 16 per million, and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Immunomodulating drugs in myelodysplastic syndromes

    ... is probably a direct cytotoxic activity on the del5q clone . This possibly specific effect is currently being investigated in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Mechanisms and Clinical Implications of Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    ... (PNH) is a rare acquired disease characterized by a clone of blood cells lacking glycosyl inostitol phosphatidyl (GPI) anchored ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Lenalidomide for treatment of myelodysplastic syndromes: current status and future directions.

    ... In del(5q) patients, lenalidomide suppresses the clone by inhibiting the nuclear sequestration of the haplodeficient cell ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Hypomethylating agents in myelodysplastic syndromes changing the inevitable: the value of azacitidine as maintenance therapy, effects on transfusion and combination with other agents.

    ... has a progressively cumulative effect on the MDS clone and support the value of maintenance therapy. Prolonged survival was ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Demonstration of additional benefit in adding lenalidomide to azacitidine in patients with higher-risk myelodysplastic syndromes.

    ... bone marrow microenvironment and the malignant clone . A recent Phase I trial testing the lenalidomide and azacitidine ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. TP53 Mutations in Low-Risk Myelodysplastic Syndromes With del(5q) Predict Disease Progression.

    ... BM samples. Results TP53 mutations with a median clone size of 11% (range, 1% to 54%) were detected in 10 patients (18%) ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia

    ... of a paroxysmal nocturnal hemoglobinuria clone (P=0.01) and a pretreatment absolute reticulocyte count ...

    Research Article last updated 07/20/2018 - 5:14pm.