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  1. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... bone marrow failure . The prevalence of the PNH clone (from <1-100% PNH granulocytes) is approximately 16 per million, and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Immunomodulating drugs in myelodysplastic syndromes

    ... is probably a direct cytotoxic activity on the del5q clone . This possibly specific effect is currently being investigated in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Mechanisms and Clinical Implications of Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    ... (PNH) is a rare acquired disease characterized by a clone of blood cells lacking glycosyl inostitol phosphatidyl (GPI) anchored ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Lenalidomide for treatment of myelodysplastic syndromes: current status and future directions.

    ... In del(5q) patients, lenalidomide suppresses the clone by inhibiting the nuclear sequestration of the haplodeficient cell ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Hypomethylating agents in myelodysplastic syndromes changing the inevitable: the value of azacitidine as maintenance therapy, effects on transfusion and combination with other agents.

    ... has a progressively cumulative effect on the MDS clone and support the value of maintenance therapy. Prolonged survival was ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Demonstration of additional benefit in adding lenalidomide to azacitidine in patients with higher-risk myelodysplastic syndromes.

    ... bone marrow microenvironment and the malignant clone . A recent Phase I trial testing the lenalidomide and azacitidine ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. TP53 Mutations in Low-Risk Myelodysplastic Syndromes With del(5q) Predict Disease Progression.

    ... BM samples. Results TP53 mutations with a median clone size of 11% (range, 1% to 54%) were detected in 10 patients (18%) ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia

    ... of a paroxysmal nocturnal hemoglobinuria clone (P=0.01) and a pretreatment absolute reticulocyte count ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Relapse after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes: Analysis of Late Relapse Using Comparative Karyotype and Chromosome Genome Array Testing

    ... were replaced by new clones, in 17.3% the same clone was present before HCT and at relapse, and in 9.7%, no abnormalities ...

    Research Article last updated 07/20/2018 - 5:15pm.