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  1. A novel marker for screening paroxysmal nocturnal hemoglobinuria using routine complete blood count and cell population data

    ... and CD15 in granulocytes to 0.1%. Twenty-four PNH minor clone -positive samples (minor-PNH+) were taken, in which the clone population was <5% of RBCs and/or granulocytes. Excluding PNH and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... the probability of developing a cytogenetically abnormal clone . A significantly increased number of telomere signal-free chromosomal ... of an autonomous and clinically detectable abnormal clone. Marrow cells of clinically healthy individuals carrying loss-of-function ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... marrow failure (BMF) syndromes and the effect of PNH clone size on hemolysis. Methods: Patients, selected from medical office ... (7.8%). Among patients with PNH clones ≥ 1%, median clone size was smaller in patients with AA (5.1%) than in those with MDS ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

    ... marrow failure (BMF) syndromes and the effect of PNH clone size on hemolysis. METHODS: Patients, selected from medical ... (7.8%). Among patients with PNH clones ≥ 1%, median clone size was smaller in patients with AA (5.1%) than in those with MDS ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... proteins is hypothesized to provide the mutant clone with an extrinsic growth advantage, but some features of PNH argue ... stepwise clonal evolution derived from a singular stem cell clone. Bone Marrow Diseases:  ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Expression of DLK1 Gene in the Bone Marrow Cells of Patients with Myelodysplastic Syndromes and Its Clinical Significance.

    ... DLK1 (≥0.8) presented significantly higher malignant clone burden (0.4134±0.3999) than those with lower DLK1 expression ... A high expression of DLK1 gene suggested a higher malignant clone burden of MDS. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes

    ... disease natural history by suppressing the malignant clone . Data discussed here from the pivotal phase 2 (MDS-003) and phase 3 ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... agent that selectively suppresses the del(5q) clone . While the mechanism is not fully understood, it is associated with ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... proteins, making red blood cells (RBC) derived from the clone more sensitive to complement mediated hemolysis . The ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. STAT3-mutations indicate the presence of subclinical T cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.

    ... of HLADR15 were found. MDSs harboring a STAT3 mutant clone showed lower degree of BM cellularity and a higher frequency ...

    Research Article last updated 07/20/2018 - 5:15pm.