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  1. Performance characteristics of consensus approaches for small and minor paroxysmal nocturnal hemoglobinuria clone determination by flow cytometry.

    Journal Title:  Clin Chem Lab Med Primary Author:  Marinov I Author(s):  Mari...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Multiparameter FLAER-based flow cytometry for screening of paroxysmal nocturnal hemoglobinuria enhances detection rates in patients with aplastic anemia

    ... detection of paroxysmal nocturnal hemoglobinuria (PNH) clone . This study aimed to compare PNH clone detection by flow cytometry in the pre-FLAER era versus the FLAER era. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... a glycosylphosphatidylinositol-anchor protein-deficient clone was detected in 83 (40%) patients pre-treatment, and the median clone size was 9.7% (interquartile range 3.5-29). In patients without a ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia.

    ... Twenty-seven patients with AA and a detectable PNH clone were monitored for a median of 5.7 years (range1.5 to 11.5 years). ... The erythrocyte and granulocyte PNH clone sizes were measured using flow cytometry and analyzed via CellQuest ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Clone of Clone of Clone of Clone of Caring for Yourself

    Another side to effective patient behavior The key to becoming an empowered patient is simply deciding to make your life the best it can be. People with bone marrow failure and other chronic diseas...

    Page last updated 04/11/2016 - 1:49pm.

  6. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes

    ... (MDS) are clonally heterogeneous, with a founding clone and multiple subclones. It is not known whether specific gene ... the range of variant allele frequencies (VAFs) for founding clone mutations. At least one mutation or cytogenetic abnormality was ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... Complete responders had a decrease in red cell clone size while good partial responders had an increase. Thirteen patients ... failure, underlying inflammatory conditions and red cell clone size following treatment. Normalization of hemoglobin with decrease in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

    ... or detectable paroxysmal nocturnal hemoglobinuria clone , irrespective of treatment. In addition to evaluating the long-term ... granulocyte paroxysmal nocturnal hemoglobinuria clone size was 68.1% (range, 0.01%-100%). Overall, 16% of patients had a ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes

    ... marrow failure, and assayed for the presence of a PNH clone in the pediatric or adult hematology/oncology clinics from 2001 to ... are needed, our results suggest that the detection of a PNH clone can be a useful diagnostic tool to exclude the diagnosis of IBMFS and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. A novel marker for screening paroxysmal nocturnal hemoglobinuria using routine complete blood count and cell population data

    ... and CD15 in granulocytes to 0.1%. Twenty-four PNH minor clone -positive samples (minor-PNH+) were taken, in which the clone population was <5% of RBCs and/or granulocytes. Excluding PNH and ...

    Research Article last updated 07/20/2018 - 5:15pm.