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  1. Research Overview - Recent Past Progress and Projections for the Near-Term

    ... there are distinct phases —basic, translational, and clinical research . Can you explain what part of the process each area of ... studies and the clinical phase, we found in our first MDS trial that there was a subset of MDS, i.e., those cases with chromosome 5q ...

    Interview last updated 02/10/2014 - 9:40am.

  2. Bone Marrow and Stem Cell Transplantation

    ... patients to a given conditioning regimen. A Phase III clinical trial is currently comparing the effects of more and less intensive ...

    Page last updated 09/30/2014 - 11:47am.

  3. Research Overview – Recent Past Progress and Projections for the Near-Term

    ... as well as director of the Division of Translational/ Clinical Research . Dr. List shares his thoughts about the developments in ... in MDS. But in the clinical phase, we found in our first MDS trial that there was a subset of MDS – patients with chromosome 5q deletion, ...

    Page last updated 01/14/2014 - 11:47am.

  4. Research Retrospective for AA&MDSIF 30th Anniversary - Dr. Neal Young

    ... often do not realize that treatments are established in clinical protocols. When I ask an audience of hundreds of patients how many are in a clinical trial , one or two raise a hand! So patients want the information, but they ...

    Interview last updated 05/08/2013 - 2:51pm.

  5. Interviews with the Experts Comorbidities: When Other Medical Conditions Affect MDS Treatment

    ... The severity of comorbid conditions is also relevant to clinical trials. Most trials of new drugs are trying to enroll a healthier ... one of the study participants has a bad event while on the trial due to a comorbid condition, it could be erroneously blamed on the drug ...

    Interview last updated 11/17/2014 - 9:31am.

  6. Interviews with the Experts Pioneering Quality of Life Research for MDS Patients

    ... issues, to name a few. In discussing these issues with my clinical mentors, we thought it would be important to measure MDS-related ... observation was that around 40% of patients on the NIH trial who were refractory to immunosuppression did have a response to ...

    Interview last updated 04/03/2014 - 2:13pm.

  7. Casey O’Connell, MD

    ... University of Southern California (USC). In addition to her clinical work with patients at the Norris Comprehensive Cancer Center, she ... clinical trials, the most exciting of which is a Phase I trial utilizing a novel hypomethylating agent for patients with MDS and acute ...

    Page last updated 04/18/2012 - 1:47pm.

  8. Resistance to Hypomethylating Agents in the Treatment of MDS

    ... to 60% to 80% overall response rates for MDS patients in clinical trials. But that still means about 25% or more patients are ... .  And for other patients, enrolling onto a clinical trial is available to them and offers a therapy that they would not ...

    Interview last updated 06/17/2014 - 9:15am.

  9. Ramon V. Tiu, MD

    ... A total of four patients were successfully enrolled in this trial. All four patients had refractory aplastic anemia. None of the patients ... single nucleotide polymorphism arrays, especially in their clinical application in myeloid malignancies like myelodysplastic ...

    Grant Recipient last updated 10/30/2012 - 6:28pm.

  10. Lower-Risk MDS: Diagnosis and Treatment Options

    ... will be considered. It is also important in designing clinical trials and applying the results of clinical trials. We do not take data from a trial involving lower-risk patients and apply them to higher-risk patients, ...

    Interview last updated 05/18/2012 - 1:28pm.