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  1. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial.

    ... Decitabine given on a 5-day schedule provided meaningful clinical benefit for patients with MDS, with more than half demonstrating ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Higher-risk myelodysplastic syndromes with del(5q): is sequential azacitidine-lenalidomide combination the way to go?

    ... and lenalidomide both have meaningful single-agent clinical activity in HR-MDS and AML with del(5q). Early-phase trials in HR-MDS ... In this article, we review the results of a Phase I trial of a sequential azacitidine-lenalidomide combination approach in patients ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. A systematic review of patient reported outcomes in phase II or III clinical trials of myelodysplastic syndromes and acute myeloid leukemia

    ... purpose of this systematic literature review was to identify clinical trials of MDS and AML that included patient-reported outcome (PRO) ... trials met all criteria (i.e., phase 2 or 3 clinical trial for MDS or AML which included PRO assessment) and were published ...

    Research Article last updated 07/18/2018 - 8:25am.

  4. Clinical consequences of iron overload in patients with myelodysplastic syndromes: the case for iron chelation therapy

    ... erythropoiesis and chronic transfusion therapy. The clinical consequences of iron overload include cardiac and/or hepatic failure, ... of using ICT in MDS. The placebo -controlled TELESTO trial ( NCT00940602 ) is currently examining the use of deferasirox in MDS ...

    Research Article last updated 07/18/2018 - 8:41am.

  5. In Treatment at NIH

    ... for a stem cell transplant as part of a new clinical trial testing the use of cord-blood stem cells with half-matched ...

    Patient Chronicle last updated 06/06/2018 - 10:03am.

  6. Low Dose Danazol for the Treatment of Telomere Related Diseases

    For more details on this clinical trial, including contact information, please see this trial’s listing on ... the efficacy, appropriateness or suitability of any clinical trial listed on this website. Pharmaceutical company sponsored ...

    Clinical Trial last updated 05/31/2018 - 2:53pm.

  7. A Phase II Study of the Combination of Azacitidine and Pembrolizumab for Patients with Myelodysplastic Syndrome (MDS)

    For more details on this clinical trial, including contact information, please see this trial’s listing on ... Purpose:  The goal of this clinical research study is to learn if azacitidine in combination ...

    Clinical Trial last updated 05/14/2018 - 1:57pm.

  8. Phase II Decitabine (DAC) Versus Azacitidine (AZA) in Myelodysplastic Syndrome (MDS)

    For more details on this clinical trial, including contact information, please see this trial’s listing on ... Purpose:  The goal of this clinical research study is to compare how 2 different drugs, decitabine ...

    Clinical Trial last updated 05/14/2018 - 1:55pm.

  9. A Phase II Study of SGI-110 in Philadelphia-Negative Myeloproliferative Neoplasms

    For more details on this clinical trial, including contact information, please see this trial’s listing on ... the efficacy, appropriateness or suitability of any clinical trial listed on this website. Pharmaceutical company sponsored ...

    Clinical Trial last updated 05/14/2018 - 2:02pm.

  10. MDS Clinical Research Consortium

    The MDS Clinical Research Consortium is an unprecedented, six-institution ... The Consortium fills a major gap in MDS-related clinical research in the United States by providing a new “critical mass” ... (data collection and management, biostatistics, clinical trial accrual, supervision of research protocols) are based at the ...

    Page last updated 05/08/2018 - 10:07am.