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  1. An update on the treatment of myelodysplastic syndromes.

    ... , are approved for intermediate-2- and high-risk MDS. Trial results have increased the understanding of these treatments, alone or ... often requires at least three to six months to achieve a clinical response. In the meantime, or in addition to active therapy, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial.

    ... Decitabine given on a 5-day schedule provided meaningful clinical benefit for patients with MDS, with more than half demonstrating ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Higher-risk myelodysplastic syndromes with del(5q): is sequential azacitidine-lenalidomide combination the way to go?

    ... and lenalidomide both have meaningful single-agent clinical activity in HR-MDS and AML with del(5q). Early-phase trials in HR-MDS ... In this article, we review the results of a Phase I trial of a sequential azacitidine-lenalidomide combination approach in patients ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. My Encounter with Aplastic Anemia

    ... once again. They sent me to the NIH for a clinical trial of eltrombopag , which after a number of trips back and forth ...

    Patient Chronicle last updated 04/26/2018 - 10:16am.

  5. My Life is Making a Difference

    ... and had gotten the information we needed to qualify for a trial. That night in the ER we knew I had to get into the program as soon as ... to be evaluated for admission to an eltrombopag clinical trial . There, after another bone marrow biopsy I was diagnosed ...

    Patient Chronicle last updated 04/26/2018 - 10:20am.

  6. Updates from John and Isabella!

    ... in this immediate post-transplant period. The clinical trial you’re now part of since arriving here in a caregiver role - how ...

    Patient Chronicle last updated 04/26/2018 - 12:08pm.

  7. MDS Clinical Research Consortium

    The MDS Clinical Research Consortium is an unprecedented, six-institution ... The Consortium fills a major gap in MDS-related clinical research in the United States by providing a new “critical mass” ... (data collection and management, biostatistics, clinical trial accrual, supervision of research protocols) are based at the ...

    Page last updated 09/19/2018 - 10:57am.

  8. Hypomethylating agents in combination with immune checkpoint inhibitors in acute myeloid leukemia and myelodysplastic syndromes

    ... inhibitors, as single-agent therapy, have shown modest clinical efficacy in the treatment of acute myeloid leukemia (AML) and ... combining HMAs with immune checkpoint blockade. Clinical trial data have shown encouraging response rates and durable responses ...

    Research Article last updated 04/11/2018 - 9:47am.

  9. Paige Cranwell: "My Half-Match Miracle"

    ... at the time my doctor at Johns Hopkins was pioneering a clinical trial studying haploid (half-match) stem cell transplants. Six months ...

    Patient Chronicle last updated 09/19/2018 - 9:49am.

  10. Simona Pagliuca, MD

    ... A and anti-thymoglobuline. In 2014 the experimental trial named RACE has been started in Europe trying to improve the results of ... research concerns the biological part arising from this clinical trial : we are trying to characterize the immunological aberration ...

    Grant Recipient last updated 08/15/2018 - 12:22pm.