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  1. Platelet count doubling after the first cycle of azacitidine therapy predicts eventual response and survival in patients with myelodysplastic syndromes and oligoblastic acute myeloid leukaemia but does not add to prognostic utility of the revised IPSS

    ... Reliable clinical or molecular predictors of benefit from azacitidine therapy ... azacitidine therapy remains an unmet medical need and a top research priority. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Molecular Testing in Myelodysplastic Syndromes for the Practicing Oncologist: Will the Progress Fulfill the Promise?

    ... The current prognostic tools sum the impact of clinical, pathologic, and laboratory parameters. Newer technologies with ... mutational data into daily clinical practice and how future research could help improve the prognostication precision and specific therapy ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Myelodysplastic syndromes in the United States: an update for clinicians

    ... most often in elderly white persons. MDS have significant clinical consequences, including cytopenias leading to infection, bleeding, ... morbidity and mortality in elderly patients. Recent research suggests MDS occurs more frequently than previously thought and may ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Lenalidomide in myelodysplastic syndromes: an erythropoiesis-stimulating agent or more?

    ... Anemia remains the most challenging clinical manifestation to treat in patients with lower-risk ... chromosomal abnormality. Lenalidomide also has meaningful clinical activity in lower-risk patients without deletion 5q. The experience ... in MDS is a modern example of reciprocal translational research, in which bench work led to an approved drug for patients, and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Genome sequencing in myelodysplastic syndromes: can molecular mutations predict benefit from hypomethylating agent therapy?

    ... many patients do not derive benefit. There is an urgent clinical need to identify patients with low probability of benefiting from ... therapies in patients with MDS remains a top clinical and a research priority. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Paroxysmal Nocturnal Hemoglobinuria: A Complement-Mediated Hemolytic Anemia

    ... largely mediated by the alternative pathway of complement. Clinical manifestations result from the lack of specific cell surface ... Complement inhibition strategies are an area of active research. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Cutting the cord from myelodysplastic syndromes: chronic myelomonocytic leukemia-specific biology and management strategies

    ... recognized as a distinct entity with unique biologic and clinical features. This change has created a scientific and clinical research landscape that makes it difficult to discern CMML-specific validated ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Genetics factors associated with myelodysplastic syndromes

    ... miR-125a and MiR-21. Somatic mutations may influence the clinical phenotype but are not included in current prognostic scoring systems. In recent years research has brought new insights into these diseases, but few of the findings ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Myelodysplastic Syndromes and Acute Myeloid Leukemia in the Elderly

    ... can influence life expectancy and treatment tolerance. Clinical trials accounting for the heterogeneity of tumor biology and ... with MDS and AML and highlights future directions for research. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.

    ... conditions and, to some extent, appear to define distinct clinical phenotypes in MDS. The high frequency of mutations in different ... targets of the spliceosome mutations is an active area of research. Emerging data from the study of the MDS transcriptome suggests that ...

    Research Article last updated 07/20/2018 - 5:15pm.