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  1. Diagnosis

    ... blasts (immature white blood cells) Damaged chromosomes (DNA) in bone marrow cells. These are called cytogenetic ...

    Topic section last updated 07/20/2018 - 5:15pm.

  2. Clonal Evolution in Aplastic Anemia is Driven by Chromosomal Instability Rather than Mutations in Myeloid Malignancy Candidate Gene

    ... short telomeres. Telomeres are located at the ends of chromosomes and help keep chromosomes stable. As people age, their telomeres become shorter. Patients who ...

    Research Review last updated 05/02/2016 - 9:20am.

  3. Prediction of outcomes after allogeneic stem cell transplantation for myelodysplastic syndromes

    ... normally, every human cell contains 22 pairs of non-sex chromosomes and one pair of sex chromosomes (the X and Y chromosomes) but in a monosomal karyotype there are at ...

    Research Review last updated 05/02/2016 - 9:29am.

  4. Coleman Lindsley, MD, PhD

    ... leukemia. Telomeres are caps that protects the ends of chromosomes from deterioration, and are important for preventing premature ...

    Grant Recipient last updated 06/05/2017 - 11:04am.

  5. Interviews with the Experts MDS Genomics: Providing ‘Street View’ Directions of Disease

    ... “Genomics” is the umbrella term for any study of chromosomes , genes, and DNA in a cell. “Genetics” is a more specific ... fit when talking about MDS because MDS doctors look at whole chromosomes and specifi c genes when trying to understand each patient’s ...

    Interview last updated 09/23/2014 - 9:30am.

  6. Specialized technique effective in identifying chromosomal abnormalities, improving prognosis for MDS

    ... cytogenetics (branch of genetics which studies the chromosomes ), and the number of cytopenias (reduction in the number of ... cytogenetics. Metaphase cytogenetics means studying chromosomes in the middle of the cell cycle (during a specific time when the ...

    Research Review last updated 05/02/2016 - 9:31am.

  7. Dr. Kasiani Myers: Acquired and Inheirited Bone Marrow Failure

    ... involve telomere diseases (the ends of our chromosomes that protect our DNA). The mutations that lead to these ...

    Interview last updated 02/14/2017 - 8:34am.

  8. Immune System Suppression and Bone Marrow Failure

    ... TERC genes, which help maintain telomeres (ends of chromosomes ), play an important role in aplastic anemia. Telomeres are ... of certain genes and changes in or losses of certain chromosomes inside bone marrow that is not working properly. The failed bone ...

    Research Review last updated 05/02/2016 - 9:15am.

  9. Prognostic value of telomere attrition in patients with aplastic anemia

    ... (special molecules for building DNA) at the ends of chromosomes that are there to protect the chromosomes from damage and breakdown. As we age over time, telomeres shorten ...

    Research Review last updated 05/02/2016 - 9:25am.

  10. Luis Batista, PhD

    ... Telomeres represent the extremities of our chromosomes and are composed of long stretches of repetitive DNA sequences ...

    Grant Recipient last updated 06/09/2015 - 9:22am.