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  1. Eltrombopag Added to IST Yields Encouraging Results

    ... length – they are the bits at the end of the chromosomes – also indicated whether patients would respond to the ...

    Interview last updated 05/24/2017 - 7:44am.

  2. Dr. Kasiani Myers: Acquired and Inheirited Bone Marrow Failure

    ... involve telomere diseases (the ends of our chromosomes that protect our DNA). The mutations that lead to these ...

    Interview last updated 02/14/2017 - 8:34am.

  3. Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene

    ... 11q23+/MLL- occurs rarely, involving different partner chromosomes and showing clinical and pathological features and disease ...

    Research Article last updated 09/19/2016 - 11:12am.

  4. Clonal Evolution in Aplastic Anemia is Driven by Chromosomal Instability Rather than Mutations in Myeloid Malignancy Candidate Gene

    ... short telomeres. Telomeres are located at the ends of chromosomes and help keep chromosomes stable. As people age, their telomeres become shorter. Patients who ...

    Research Review last updated 05/02/2016 - 9:20am.

  5. Prediction of outcomes after allogeneic stem cell transplantation for myelodysplastic syndromes

    ... normally, every human cell contains 22 pairs of non-sex chromosomes and one pair of sex chromosomes (the X and Y chromosomes) but in a monosomal karyotype there are at ...

    Research Review last updated 05/02/2016 - 9:29am.

  6. Specialized technique effective in identifying chromosomal abnormalities, improving prognosis for MDS

    ... cytogenetics (branch of genetics which studies the chromosomes ), and the number of cytopenias (reduction in the number of ... cytogenetics. Metaphase cytogenetics means studying chromosomes in the middle of the cell cycle (during a specific time when the ...

    Research Review last updated 05/02/2016 - 9:31am.

  7. Immune System Suppression and Bone Marrow Failure

    ... TERC genes, which help maintain telomeres (ends of chromosomes ), play an important role in aplastic anemia. Telomeres are ... of certain genes and changes in or losses of certain chromosomes inside bone marrow that is not working properly. The failed bone ...

    Research Review last updated 05/02/2016 - 9:15am.

  8. Prognostic value of telomere attrition in patients with aplastic anemia

    ... (special molecules for building DNA) at the ends of chromosomes that are there to protect the chromosomes from damage and breakdown. As we age over time, telomeres shorten ...

    Research Review last updated 05/02/2016 - 9:25am.

  9. StemRegenin-1 Expanded vs Unexpanded UCB for High Risk Heme Malignancies

    ... slow early response at Day 14, or Hypodiploidy (< 44 chromosomes or DNA index < 0.81), or End of induction M3 bone ...

    Clinical Trial last updated 06/03/2016 - 2:37pm.

  10. Dr. Vivienne Rebel reviews a recent study about p53 protein levels as a prognostic factor in MDS

    ... (i.e., the disappearance of cells with abnormal chromosomes , in this case cells that harbored a deletion of the long arm of ...

    Research Review last updated 05/02/2016 - 9:17am.