Search | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. Let’s Go FISH-ing!

    ... fluorescent dyes that attach to specific parts of the chromosomes and can detect changes in blood cancer cells. This method is ... There are four major types of abnormalities found in chromosomes that will appear through FISH: Portion of the chromosome is ...

    Article last updated 08/30/2018 - 1:28pm.

  2. Reciprocal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemias: Review of 5,654 patients with an evaluable karyotype.

    ... Journal Title:  Genes Chromosomes Cancer Primary ... in 183 (86%) cases and unbalanced in 30 (14%) cases. All chromosomes were found to be involved in translocations, with the single ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Genetics factors associated with myelodysplastic syndromes

    ... common alterations, and often involve the long arms of chromosomes 5, 7, 8, 13, and 20 and the short arms of chromosomes 12 and 17. The advent of new technologies for the detection of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Specific abnormalities versus number of abnormalities and cytogenetic scoring systems for outcome prediction after allogeneic hematopoietic SCT for myelodysplastic syndromes

    ... was adversely influenced by del 5q/-5, abnormalities of chromosomes 11 and 17 and cytogenetic IPSS-R very poor category. Karyotype with ⩽2 abnormalities and no abnormalities of chromosomes 3, 5, 7, 11 and 17 was an independent prognostic factor of lower ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. MicroRNA-194-5p could serve as a diagnostic and prognostic biomarker in myelodysplastic syndromes

    ... was to investigate the involvement of miRNAs encoded by chromosomes 8 and 1q in MDS. For this, the expression of nine miRNAs ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... ends. As such, they prevent the natural ends of linear chromosomes from being subjected to DNA repair activities that would result ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Coalesced Multicentric Analysis of 2,351 Patients With Myelodysplastic Syndromes Indicates an Underestimation of Poor-Risk Cytogenetics of Myelodysplastic Syndromes in the International Prognostic Scoring System.

    ... cytogenetics, 4.8 for complex abnormalities harboring chromosomes 5 and/or 7, and 3.1 for a blast count of 21% to 30% (P < .01 ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Low Dose Danazol for the Treatment of Telomere Related Diseases

    ... develops and works. Telomeres are found on the end of chromosomes in DNA. Some people with short telomeres or other gene changes ...

    Clinical Trial last updated 05/31/2018 - 2:53pm.

  9. Causes

    ... anemia is due to excessive shortening of the ends of chromosomes , called telomeres. This is usually diagnosed in adults. Family ...

    Topic section last updated 07/20/2018 - 5:15pm.

  10. Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene

    ... 11q23+/MLL- occurs rarely, involving different partner chromosomes and showing clinical and pathological features and disease ...

    Research Article last updated 09/19/2016 - 11:12am.