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  1. Optimization of therapy for severe aplastic anemia based on clinical, biologic, and treatment response parameters: conclusions of an international working group on severe aplastic anemia convened by the Blood and Marrow Transplant Clinical Trials Network.

    ... Journal Title:  Biol Blood Marrow Transplant Primary Author:  ... the basic science, immunosuppressive therapy (IST), and bone marrow transplantation (BMT) of SAA and propose initiatives to ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Eltrombopag and improved hematopoiesis in refractory aplastic anemia

    ... anemia , which is characterized by immune-mediated bone marrow hypoplasia and pancytopenia , can be treated effectively with ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Mesenchymal stromal cell density is increased in higher grade myelodysplastic syndromes and independently predicts survival

    ... cell (MSC) density in cytopenic patients who underwent bone marrow biopsy to evaluate for myelodysplastic syndromes (MDS). ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... Journal Title:  Biol Blood Marrow Transplant Primary Author:  ... hemolysis , venous- thrombosis , and bone marrow failure . Seventeen patients with debilitating PNH, including 8 ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myeloid leukemia following aplastic anemia

    ... Journal Title:  Biol Blood Marrow Transplant Primary Author:  ... 4.4 to 26.7 years), patients underwent HSCT with bone marrow (n = 6) or peripheral blood stem cell (n = 11) grafts from ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... an immune-mediated and life-threatening form of acquired bone marrow failure (BMF), characterized by development and expansion of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Methylation of the p73 gene in patients with myelodysplastic syndromes: correlations with apoptosis and prognosis

    ... was analyzed by methylation-specific PCR (MS-PCR) in bone marrow (BM) samples from 126 adult patients with de novo MDS. The ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Eltrombopag in aplastic anemia

    ... is evidence that this drug works by directly stimulating marrow stem and progenitor cells thereby promoting hematopoietic recovery in patients with bone marrow failure . Several trials are ongoing in our institution using ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine.

    ... RAEB-1 in 20%, RAEB-2 in 54%, and RAEB-t (AML with 21%-30% marrow blasts ) in 22%. Cytogenetic risk was good in 31%, intermediate ... low-dose cytosine arabinoside treatment (P = .009), bone marrow blasts > 15% (P = .004), and abnormal karyotype (P = .03) ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... that manifests with hemolytic anemia and bone marrow failure . Eculizumab has been shown to improve anemia, ...

    Research Article last updated 07/20/2018 - 5:14pm.