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  1. Myelodysplastic syndromes: an update on molecular pathology.

    ... by impaired peripheral blood cell production due to bone marrow dysplasia affecting one or more of the major myeloid cell lines. MDS ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. The diagnosis and treatment of aplastic anemia: a review

    ... is a rare disorder characterized by suppression of bone marrow function resulting in progressive pancytopenia . A ... pathogenetic mechanism leading to the overproduction of bone marrow -inhibiting cytokines. Immuno-mediated pathogenesis is ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. HLA-Matched Sibling Transplantation for Severe Aplastic Anemia: Impact of HLA DR15 Antigen Status on Engraftment, Graft-versus-Host Disease, and Overall Survival.

    ... Journal Title:  Biol Blood Marrow Transplant Primary Author:  ... (SAA). We studied 1204 recipients of HLA-matched sibling bone marrow transplantation for SAA to determine whether HLA DR15 status ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... numerical and structural abnormalities were observed in bone marrow cells of patients with shorter telomeres in comparison with patients ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Intravenous infusion of allogeneic mesenchymal stromal cells in refractory or relapsed aplastic anemia

    ... unrelated non-human leukocyte antigen-matched bone marrow -derived mesenchymal stromal cells (MSCs) (median, 2.7 × 10(6) ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Stem Cell Transplant from Unrelated Donor in Patients with Severe Aplastic Anemia: Indications, Donor Selection, Conditioning, GVHD Prophylaxis

    ... by pancytopenia associated with an empty or a fatty bone marrow. Historically the two treatments option have been immunosuppressive ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Paroxysmal nocturnal hemoglobinuria

    ... Paroxysmal nocturnal hemoblobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia , ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Immunosuppressive therapy for transplant-ineligible aplastic anemia patients

    ... Aplastic anemia is a rare life-threatening bone marrow failure that is characterized by bicytopenia or pancytopenia ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia

    ... as severe aplastic anemia . While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... of PNH include evidence of hemolytic anemia , bone marrow failure , smooth muscle dystonias and thromboses. Treatment options ...

    Research Article last updated 07/20/2018 - 5:15pm.