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  1. How I treat paroxysmal nocturnal hemoglobinuria.

    ... disorder that manifests with hemolytic anemia , bone marrow failure , and thrombosis . Many of the clinical ... intravascular hemolysis . Allogeneic bone marrow transplantation is the only curative therapy for PNH. ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... malignancies that are characterized by defective bone marrow hematopoiesis and by the occurrence of intramedullary ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromes

    ... cytokines, such as tumor necrosis factor-alpha (TNF-α), in marrow and abnormal activation of the p38 mitogen-activated protein kinase ... MAPK and the c-Jun N-terminal kinase (JNK) pathway in bone marrow mononuclear cells from MDS patients or normal donors in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Identification of Gene Expression-Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes.

    ... (MDS) is largely dependent on morphologic examination of bone marrow aspirates. Several criteria that form the basis of the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. The different immunoregulatory functions of mesenchymal stem cells in patients with low-risk or high-risk myelodysplastic syndromes

    ... (MDS) are a group of progressive, clonal, neoplastic bone marrow disorders characterized by hematopoietic stem cell dysregulation and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Myelodysplastic syndromes

    ... with cytopenia (s), functional abnormalities of bone marrow lineages, morphologic dysplasia, and a progression to acute myeloid ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Comparison of genetic and clinical aspects in patients with acute myeloid leukemia and myelodysplastic syndromes all with more than 50% of bone marrow erythropoietic cells.

    ... leukemia (erythropoiesis in ≥50% of nucleated bone marrow cells; ≥20% myeloblasts of non-erythroid cells) from other ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Clinical management of aplastic anemia.

    ... Acquired aplastic anemia is a potentially fatal bone marrow failure disorder that is characterized by pancytopenia and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up.

    ... aplastic anemia (SAA) is a life-threatening bone marrow failure disorder that can be treated with bone marrow transplantation, immunosuppressive therapy, and high-dose ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. High levels of vascular endothelial growth factor protein expression are associated with an increased risk of transfusion dependence in myelodysplastic syndromes

    ... growth factor (VEGF) protein expression in 79 bone marrow biopsy specimens of patients with myelodysplastic syndromes ...

    Research Article last updated 07/20/2018 - 5:15pm.