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  1. Validation of a Prognostic Model and the Impact of Mutations in Patients With Lower-Risk Myelodysplastic Syndromes

    ... with low- or intermediate-1 IPSS risk MDS and examined bone marrow samples from these patients for mutations in 22 genes, including ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Historical perspectives on myelodysplastic syndromes

    ... what we think we know now about these still-enigmatic bone marrow diseases. Here, I review a number of developments that collectively ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Immunomodulatory Drugs: New Options for the Treatment of Myelodysplastic Syndromes

    ... myeloid leukemia. Until recently, the only treatment was bone marrow transplantation, but, over the past few years, a new therapeutic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... hemolytic anemia , thrombophilia, and bone marrow failure . PNH is due to a somatic, acquired mutation in the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Spontaneous remision of aplastic anemia occurring during a pregnancy

    ... by destruction of pluripotent stem cells in bone marrow . The occurrence of aplastic anemia during pregnancy is rare and can ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Paroxysmal nocturnal hemoglobinuria

    ... hemoglobinuria and myelodysplastic syndrome are bone marrow failure diseases that can also be associated with similar aberrant ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Rabbit-antithymocyte globulin combined with cyclosporin A as a first-line therapy: improved, effective, and safe for children with acquired severe aplastic anemia.

    ... characterized by pancytopenia and hypoplastic bone marrow . Immunosuppression with anti-thymocyte globulin (ATG) and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Treatment of acquired aplastic anemia in children

    ... pancytopenia resulting from non-function of the bone marrow . The incidence of AA is approximately 3 fold more common in East ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Successful Use of Eculizumab in a Pediatric Patient Treated for Paroxysmal Nocturnal Hemoglobinuria

    ... use in pediatrics, we report a young PNH patient with bone marrow failure and severe episodes of hemolytic anemia who was ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... granulocyte colony-stimulating factor-mobilized bone marrow and peripheral blood from HLA antigen-haploidentical donors ...

    Research Article last updated 07/20/2018 - 5:14pm.