Search | Page 12 | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. Eltrombopag in aplastic anemia

    ... is evidence that this drug works by directly stimulating marrow stem and progenitor cells thereby promoting hematopoietic recovery in patients with bone marrow failure . Several trials are ongoing in our institution using ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine.

    ... RAEB-1 in 20%, RAEB-2 in 54%, and RAEB-t (AML with 21%-30% marrow blasts ) in 22%. Cytogenetic risk was good in 31%, intermediate ... low-dose cytosine arabinoside treatment (P = .009), bone marrow blasts > 15% (P = .004), and abnormal karyotype (P = .03) ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... that manifests with hemolytic anemia and bone marrow failure . Eculizumab has been shown to improve anemia, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Aplastic anemia: pathophysiology and treatment.

    ... Journal Title:  Biol Blood Marrow Transplant Primary Author:  ... poor outcome in older patients. The lack of a suitable bone marrow donor for all patients who need a transplant, illustrates the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Syngeneic transplantation in aplastic anemia: pretransplant conditioning and peripheral blood are associated with improved engraftment - an observational study on behalf of the Severe Aplastic Anemia and Pediatric Diseases Working Parties of the European

    ... aplastic anemia reported to the European Group for Blood and Marrow Transplantation. Between 1976 and 2009, 88 patients received 113 ... by posttransplant immunosuppression. Graft source was bone marrow in the majority of cases (n=77). Transplant practice changed ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Prognostic value of telomere attrition in patients with aplastic anemia.

    ... possible mechanistic insight into genomic instability of bone marrow cells derived from patients with critically short telomeres and/or ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Oral Azacitidine (CC-486) for the Treatment of Myelodysplastic Syndromes and Acute Myeloid Leukemia

    ... by malignant clones of myeloid lineage in the bone marrow and peripheral blood, with dissemination into tissues. The cytidine ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases

    ... findings with de novo MDS/AML. Consecutive bone marrow samples of 498 patients, including 70 therapy-related (28 MDS and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... we used comparative whole exome sequencing of paired bone marrow and skin samples in 22 patients. We found somatic mutations in 16 ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndromes

    ... hematopoiesis in one or more lineages of the bone marrow . In the last decade there has been a revolution in our knowledge of ...

    Research Article last updated 07/20/2018 - 5:15pm.