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  1. Prognostic value of telomere attrition in patients with aplastic anemia.

    ... possible mechanistic insight into genomic instability of bone marrow cells derived from patients with critically short telomeres and/or ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Oral Azacitidine (CC-486) for the Treatment of Myelodysplastic Syndromes and Acute Myeloid Leukemia

    ... by malignant clones of myeloid lineage in the bone marrow and peripheral blood, with dissemination into tissues. The cytidine ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... we used comparative whole exome sequencing of paired bone marrow and skin samples in 22 patients. We found somatic mutations in 16 ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndromes

    ... hematopoiesis in one or more lineages of the bone marrow . In the last decade there has been a revolution in our knowledge of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Current and novel therapeutic approaches in myelodysplastic syndromes

    ... achievement of cytogenetic remissions, and reduction in bone marrow blasts . 5-azacitidine has also been shown to improve ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes

    ... C-allele may influence predisposition to del(5q) MDS. Bone marrow and blood DNA was sequenced from 705 MDS cases (333 del(5q), 372 ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases

    ... findings with de novo MDS/AML. Consecutive bone marrow samples of 498 patients, including 70 therapy-related (28 MDS and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Self-perception of symptoms of anemia and fatigue before and after blood transfusions in patients with myelodysplastic syndromes

    ... (MDS) constitute a heterogeneous group of clonal bone marrow disorders characterized by chronic refractory anemia ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Improved risk stratification by the integration of the revised International Prognostic Scoring System with the Myelodysplastic Syndromes Comorbidity Index

    ... Myelodysplastic syndromes (MDS) comprise bone marrow failure diseases with a diverse clinical outcome. For improved risk ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... with a complement-mediated hemolytic anemia , bone marrow failure and a propensity for thrombosis . These patients ...

    Research Article last updated 07/20/2018 - 5:15pm.