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  1. Eltrombopag in aplastic anemia

    ... is evidence that this drug works by directly stimulating marrow stem and progenitor cells thereby promoting hematopoietic recovery in patients with bone marrow failure . Several trials are ongoing in our institution using ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Improved risk stratification by the integration of the revised International Prognostic Scoring System with the Myelodysplastic Syndromes Comorbidity Index

    ... Myelodysplastic syndromes (MDS) comprise bone marrow failure diseases with a diverse clinical outcome. For improved risk ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... with a complement-mediated hemolytic anemia , bone marrow failure and a propensity for thrombosis . These patients ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Biosimilar epoetin in elderly patients with low-risk myelodysplastic syndromes improves anemia, quality of life, and brain function

    ... of clonal hematopoietic disorders characterized by bone marrow failure and a risk of progression to acute myeloid leukemia (AML). ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

    ... disease associated with hemolytic anemia , bone marrow failure , thrombosis , and, frequently, poor quality of life. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. The myelodysplastic syndrome as a prototypical epigenetic disease.

    ... of apoptosis and eventual symptoms related to bone marrow failure . Cellular differentiation is an epigenetic process that ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.

    ... aplastic anemia (AA) is a rare life-threatening bone marrow failure syndrome, caused by autoimmune destruction of hematopoietic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... , renal impairment, pulmonary hypertension, and bone marrow failure . The prevalence of the PNH clone (from <1-100% PNH ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... hemolytic anemia , thrombophilia, and bone marrow failure . PNH is due to a somatic, acquired mutation in the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Immunomodulatory treatment of myelodysplastic syndromes: antithymocyte globulin, cyclosporine, and alemtuzumab

    ... MDS might share with SAA an autoimmune basis for the bone marrow failure common to both conditions. The idea was supported by reports ...

    Research Article last updated 07/20/2018 - 5:14pm.