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  1. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... an immune-mediated and life-threatening form of acquired bone marrow failure (BMF), characterized by development and expansion of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Eltrombopag in aplastic anemia

    ... is evidence that this drug works by directly stimulating marrow stem and progenitor cells thereby promoting hematopoietic recovery in patients with bone marrow failure . Several trials are ongoing in our institution using ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Improved risk stratification by the integration of the revised International Prognostic Scoring System with the Myelodysplastic Syndromes Comorbidity Index

    ... Myelodysplastic syndromes (MDS) comprise bone marrow failure diseases with a diverse clinical outcome. For improved risk ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... with a complement-mediated hemolytic anemia , bone marrow failure and a propensity for thrombosis . These patients ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Biosimilar epoetin in elderly patients with low-risk myelodysplastic syndromes improves anemia, quality of life, and brain function

    ... of clonal hematopoietic disorders characterized by bone marrow failure and a risk of progression to acute myeloid leukemia ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

    ... disease associated with hemolytic anemia , bone marrow failure , thrombosis , and, frequently, poor quality of life. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. The myelodysplastic syndrome as a prototypical epigenetic disease.

    ... of apoptosis and eventual symptoms related to bone marrow failure . Cellular differentiation is an epigenetic process that ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.

    ... aplastic anemia (AA) is a rare life-threatening bone marrow failure syndrome, caused by autoimmune destruction of hematopoietic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... hemolytic anemia , thrombophilia, and bone marrow failure . PNH is due to a somatic, acquired mutation in the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... , renal impairment, pulmonary hypertension, and bone marrow failure . The prevalence of the PNH clone (from <1-100% PNH ...

    Research Article last updated 07/20/2018 - 5:15pm.