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  1. Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors

    ... Pediatric acquired aplastic anemia (AA) is a bone marrow disorder that is difficult to distinguish from inherited bone ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Somatic mutations identify a sub-group of aplastic anemia patients that progress to myelodysplastic syndrome

    ... is based solely on morphological changes in blood and bone marrow . We postulated that somatic mutations are present in a subset of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Myelodysplastic syndromes: What do hospitalists need to know?

    ... in any patient with unexplained cytopenias, and a bone marrow evaluation is ultimately needed to make the diagnosis and exclude ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Reduced ribosomal RNA expression and increased ribosomal DNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes

    ... increases in DNA methylation have been documented in bone marrow cells from MDS patients, the methylation signatures of specific gene ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. The complex pathophysiology of acquired aplastic anemia

    ... that intrinsic and/or secondary deficits in HSPCs and bone marrow mesenchymal stem cells may underlie the development of bone ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Tips for Managing Fatigue

    ... are not alone. Most patients who are diagnosed with a bone marrow failure disease say they experience fatigue. In fact, one study ...

    Facts for Life last updated 07/25/2018 - 10:38am.

  7. Hematopoietic stem cell transplantation for aplastic anemia and paroxysmal nocturnal hemoglobinuria: current evidence and recommendations

    ... Aplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia and an empty ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. How I treat paroxysmal nocturnal hemoglobinuria.

    ... disorder that manifests with hemolytic anemia , bone marrow failure , and thrombosis . Many of the clinical manifestations of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    ... The most significant clinical features of PNH include: bone marrow failure , intravascular hemolysis , and thrombosis . To ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Fludarabine-based conditioning for marrow transplantation from unrelated donors in severe aplastic anemia: early results of a cyclophosphamide dose deescalation study show life-threatening adverse events at predefined cyclophosphamide dose levels

    ... Journal Title:  Biol Blood Marrow Transplant Primary Author:  ... in a fludarabine -based conditioning regimen for bone marrow transplantation from unrelated donors in patients with severe ...

    Research Article last updated 07/20/2018 - 5:14pm.