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  1. CHIP – A Promising Genetic Discovery for MDS, AML and Cardiovascular Disease

    ... studying how genetic mutations impact the progression of bone marrow failure have discovered how these mutations may also affect ...

    Article last updated 08/30/2018 - 3:14pm.

  2. Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia.

    ... Severe aplastic anemia (AA) is a bone marrow (BM) failure (BMF) disease frequently caused by aberrant immune ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Aplastic Anemia & MDS International Foundation: Bone marrow failure disease scientific symposium 2012

    ... possible mechanistic insight into genomic instability of bone marrow cells derived from patients with critically short telomeres and/or ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Bone marrow mesenchymal stem cells from aplastic anemia patients preserve functional and immune properties and do not contribute to the pathogenesis of the disease

    ... Aplastic anemia is a life-threatening bone marrow failure disorder characterized by peripheral pancitopenia and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Diagnosis and management of acquired aplastic anemia in childhood. Guidelines from the Marrow Failure Study Group of the Pediatric Haemato-Oncology Italian Association (AIEOP)

    ... characterized by pancytopenia and hypoplastic bone marrow . The incidence is 2-3/million inhabitants/year, in Europe, but ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Unveiling the paradoxical nature of myelodysplastic syndromes (MDS): Why hypercellular marrow strongly favors accelerated apoptosis.

    ... The pathogenesis of bone marrow failure in myelodysplastic syndromes (MDS) is an unresolved ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndromes

    ... hematopoiesis in one or more lineages of the bone marrow . In the last decade there has been a revolution in our knowledge of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Pediatric myelodysplastic syndromes: they do exist!

    ... cytopenia (s) and normal or hypercellular bone marrow with dysplasia in ≥1 blood cell lineages. MDS frequently evolves ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors

    ... Pediatric acquired aplastic anemia (AA) is a bone marrow disorder that is difficult to distinguish from inherited bone ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Somatic mutations identify a sub-group of aplastic anemia patients that progress to myelodysplastic syndrome

    ... is based solely on morphological changes in blood and bone marrow . We postulated that somatic mutations are present in a subset of ...

    Research Article last updated 07/20/2018 - 5:15pm.