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  1. Myelodysplastic syndromes: 2012 update on diagnosis, risk-stratification, and management

    ... group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous ... Risk-adapted therapy: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts, and, more recently, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Myelodysplastic syndromes: 2011 update on diagnosis, risk-stratification, and management

    ... group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous ... RISK-ADAPTED THERAPY: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts and more recently cytogenetic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Comparison of Rabbit Antithymocyte Globulin (R-ATG) and Jurkat Cell-Reactive Anti-T Lymphocyte Globulin (ATG-F) as a First-line Treatment for Children with Aplastic Anemia

    ... AA (SAA), 10 cases of very severe AA (VSAA) and 11 cases of transfusion-dependent non-severe AA (NSAA). While receiving immunosuppressive ... and/or infection control. Absolute counts of peripheral blood lymphocyte (ALC) in various time points were dynamically measured after ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... factor-mobilized bone marrow and peripheral blood from HLA antigen-haploidentical donors (3 cases) or peripheral ... no chronic GvHD was documented. All patients were alive and transfusion independent at a median follow-up of 15 months (range: 6-29 ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... The purpose of this study was to observe the outcome of co-transfusion of umbilical cord multipotent stromal cells (UC-MSC) and allogeneic ... factor-primed bone marrow and peripheral blood grafts; the other patients received granulocyte colony-stimulating ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Clinical and genetic predictors of prognosis in myelodysplastic syndromes

    ... Most models include the presence or severity of peripheral blood cytopenias, the proportion of bone marrow blasts , and ... factors including age, performance status, co-morbidities, transfusion dependence, and molecular biomarkers can further refine the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Molecular pathogenesis of myelodysplastic syndromes

    ... , hypercellular bone marrow , dysplasia of blood cells and cytopenias. Most patients are diagnosed in their late 60s to ... decitabine , and 5-azacytidine, are targeted to improve transfusion requirements and quality of life. Moreover, 5-azacytidine has also ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Azacitidine in the management of patients with myelodysplastic syndromes.

    ... of treatment for MDS was supportive care , including transfusion of blood products and growth factors. Further understanding of disease biology led ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Supportive care in severe and very severe aplastic anemia

    ... early treatment of fungal, bacterial and viral infections, transfusion strategy and iron chelation and assess the evidence basis. In fact, ... infections and of secondary events like alloimmunization to blood products and iron overload have a significant impact on the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Therapeutic modalities for patients with lower-risk myelodysplastic syndromes: current options and future directions.

    ... goals of treatment include improvement of peripheral blood cytopenias, reduction of transfusions, improvement of the quality of ... , warrants treatment in an attempt to eliminate transfusion dependence. This article reviews current treatment strategies for ...

    Research Article last updated 07/20/2018 - 5:14pm.