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  1. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... gene, which impairs the membrane expression on affected blood cells of a number of proteins, including the complement regulators CD55 ... leading to hemoglobin stabilization and transfusion independence in more than half of the patients. However, recent ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia

    ... to 20%. Oral and SC azacitidine decreased DNA methylation in blood, with maximum effect at day 15 of each cycle. Hematologic responses ... remission, hematologic improvement, or RBC or platelet transfusion independence) was 35% in previously treated patients and 73% in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Ron Carlsen Beats Early Onset MDS; Grapples with Post-Transplant GVHD

    ... started to bruise easily with no explanation, and my red blood cell count started to drop. Eventually, I was put on epoetin alfa ... lenalidomide. By October 2006, I had become blood transfusion dependent, requiring one each week. The new problem was my ...

    Patient Chronicle last updated 07/25/2018 - 10:28am.

  4. Iron status and treatment modalities in transfusion-dependent patients with myelodysplastic syndromes.

    ... Transfusion dependency and iron overload are common among patients with ... myelodysplastic syndromes (MDS) treated with red blood cell (RBC) transfusions. Transfusion dependency is associated with ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Myelodysplastic syndromes and the role of iron overload.

    ... in patients with MDS due to the long-term use of red blood cell transfusions in patients with symptomatic anemia . ... options for patients with MDS do not always reduce the transfusion burden, many patients will still need long-term transfusion ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena

    ... months (range 6-46 months). Parameters of hemolysis , transfusion requirements, and serum iron parameters were analyzed. Lactate ... low reticulocyte production index and/or requiring blood transfusions. Monospecific direct Coombs test was positive in most PNH ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Clinical utility of lenalidomide in the treatment of myelodysplastic syndromes

    ... Journal Title:  J Blood Med Primary Author:  ... del(5q) MDS, including reduction in red blood cell transfusion requirements and improvements in quality of life. Lenalidomide has ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Iron overload in myelodysplastic syndromes: diagnosis and management.

    ... stem cell malignancies characterized by ineffective blood cell production. Many MDS patients are dependent on red blood cell ... MDS whose expected survival is measured in years. Transfusion dependence is associated with shorter survival and an increased ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Costs and quality of life in patients with myelodysplastic syndromes.

    ... Journal Title:  Am J Blood Res Primary Author:  ... and the impact on quality of life (QOL) of MDS-separately in transfusion-independent (TI) and -dependent (TD) patients-a literature search ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes

    ... is approved for the treatment of patients who have transfusion-dependent anemia due to lower-risk MDS with chromosome 5q ... that lenalidomide is effective not only in reducing red blood cell (RBC) transfusion burden, but also in modifying the disease ...

    Research Article last updated 07/20/2018 - 5:15pm.