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  1. The clinical, quality of life, and economic consequences of chronic anemia and transfusion support in patients with myelodysplastic syndromes

    ... associated with transfusions, chronic anemia and red blood cell (RBC) transfusion dependence impact negatively on survival and quality of life (QoL), ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Polymorphism of the complement receptor 1 gene correlates with hematological response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

    ... the response is variable and some patients remain red blood cell transfusion -dependent. In 72 patients with hemolytic Paroxysmal Nocturnal ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. The immunomodulatory agents lenalidomide and thalidomide for treatment of the myelodysplastic syndromes: A clinical practice guideline.

    ... with the aging population. Treatment includes red blood cell transfusion for anemia . The immunomodulatory agents (imids) ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Self-perception of symptoms of anemia and fatigue before and after blood transfusions in patients with myelodysplastic syndromes

    ... anemia . Many patients with MDS are dependent on regular blood transfusions. The study aimed to investigate symptoms of anemia and ... in patients with MDS immediately before and after blood transfusion and to capture patients' descriptions of their symptoms. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Blood stream infection after stem cell transplantation in children with idiopathic aplastic anemia

    ... Journal Title:  Biol Blood Marrow Transplant Primary ... transplantation from unrelated donors, frequent blood transfusion before transplantation, major or major+minor mismatch of ABO ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Long-term follow-up of patients with moderate aplastic anemia and pure red cell aplasia treated with daclizumab.

    ... Previously, we described short-term improvements in blood counts in two pilot studies treating moderate aplastic anemia (mAA) and ... achieved long-term packed red blood cell PRBC transfusion independence , and all PRCA responders achieved long-term ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Durable long-term responses in patients with myelodysplastic syndromes treated with lenalidomide.

    ... has proven efficacy and safety and has been shown to reduce transfusion requirements and reverse cytogenetic abnormalities in lower-risk ... of these patients had an ongoing requirement for red blood cell transfusions despite previous treatment with recombinant ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Development and validation of a model to predict platelet response to romiplostim in patients with lower-risk myelodysplastic syndromes

    ... endogenous erythropoietin levels and limited red blood cell transfusion history can predict response to erythropoiesis-stimulating agents ... Variables including baseline endogenous THPO levels, transfusion needs, and platelet response were analysed in a randomized trial ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Variations in erythropoiesis-stimulating agent administration in transfusion-dependent myelodysplastic syndromes impact response

    ... Erythropoiesis-stimulating agents (ESAs) reduce red blood cell (RBC) transfusions in approximately 40% of patients with ... The study cohort consisted of patients with new-onset transfusion dependence (TD). All patients received an ESA at least once during ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Front-line immunosuppressive treatment of acquired aplastic anemia

    ... 60 and 80%. CsA should be given for 12 months until transfusion independence is achieved and then tapered very slowly in the ... are usually continued on CsA. Tight monitoring of the blood count during CsA tapering is necessary to identify early loss of ...

    Research Article last updated 07/20/2018 - 5:14pm.