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  1. TCRαβ+/CD19+ Depleted Haploidentical HSCT + Zoledronate

    ... with a haploidentical donor peripheral blood stem cell graft depleted of TCRαβ+ cells and CD19+ cells in conjunction with the ... therapy- refractory AML with bone marrow blast < 20% High-risk refractory or relapsed ALL in patients for whom ...

    Clinical Trial last updated 04/29/2016 - 4:35pm.

  2. Nonmyeloablative Allogeneic Transplant (Mini-allo)

    ... RAEBiT, CMMoL) CML (chronic phase; accelerated phase; blast phase following reinduction attempt; 2nd chronic or accelerated phase ... Lymphoma Aggressive Histology (includes T Cell NHL) Incomplete response to induction Second CR Sensitive or ...

    Clinical Trial last updated 04/28/2016 - 2:13pm.

  3. Allo HSCT Using RIC for Hematological Diseases

    ... followed by a related or unrelated donor stem cell infusion. The primary objective is to evaluate rates of acute ... Chronic Myelogenous Leukemia excluding refractory blast crisis: To be eligible in first chronic phase (CP1) patient must have ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  4. UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep

    ... lymphoma in CR2 or subsequent CR Natural killer cell malignancies Chronic myelogenous leukemia (CML): all types except refractory blast crisis. Chronic phase patients must have failed or been intolerant to at ...

    Clinical Trial last updated 04/29/2016 - 10:06am.

  5. Phase I/II MEK162 Relapsed and/or Refractory Acute Myeloid Leukemia (AML) and Poor Prognosis, Not Suitable for or Unwilling to Receive Standard Therapy

    ... or high risk (RAEB-2 only, i.e. greater than or equal to 10% blast) who are resistant or intolerant to standard treatment and are not ... with active other tumors, except early stage squamous cell carcinoma of the skin, basal cell carcinoma of the skin, or cervical ...

    Clinical Trial last updated 06/06/2016 - 10:59am.

  6. GVHD Prophylaxis With Post Transplant Cyclophosphamide for Patients With Renal Insufficiency Undergoing a Conventional 8/8 HLA-matched Related or Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplant

    ... GVHD is one of the most common complications of a stem cell transplant . Status:  ... second chronic phase, or in CR after accelerated phase or blast crisis. Non-Hodgkins lymphoma with chemoresponsive disease in any ...

    Clinical Trial last updated 04/29/2016 - 12:40pm.

  7. Natural Killer (NK) Cells With HLA Compatible Hematopoietic Transplantation for High Risk Myeloid Malignancies

    ... that can be given with chemotherapy and a stem cell transplant to patients with AML and MDS. Researchers want to learn if ... relapse; or (ii) has ever been in accelerated phase or blast crisis. Patient must have an identified a HLA (A,B,C,DR) ...

    Clinical Trial last updated 06/06/2016 - 1:18pm.

  8. Specialized technique effective in identifying chromosomal abnormalities, improving prognosis for MDS

    ... given more weight than previously, different cut-offs for blast percentage, and sensitivity to degrees of cytopenias. Furthermore, ... cytogenetics means studying chromosomes in the middle of the cell cycle (during a specific time when the cell is actively dividing). This ...

    Research Review last updated 05/02/2016 - 9:31am.

  9. Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

    ... Background: - In allogeneic stem cell transplantation (SCT), stem cells are taken from a donor and given ... MDS/RAEB-I or II or CML with previous accelerated or blast phase must have < 5% blasts in the peripheral blood and bone ...

    Clinical Trial last updated 04/29/2016 - 1:00pm.

  10. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... status, organ function, prior transplantation, hematopoietic cell transplant comorbidity index (HCT-CI)23, and CB TNC dose into those who ... Any acute leukemia (including prior myelodysplasia or CML blast crisis) with morphologic relapse or persistent disease ≥ 10% blasts ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.