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  1. Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children

    ... This phase II trial studies how well T cell depleted donor peripheral blood stem cell transplant works in ... or primary refractory disease with a circulating blast count of no more than 10,000/mm^3 Acute myeloid leukemia in relapse ...

    Clinical Trial last updated 06/13/2016 - 2:29pm.

  2. Selective Depletion of CD45RA+ Naive T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors for Prevention of GVHD

    ... This phase II trial studies how well selective T cell depletion works in preventing graft-versus-host disease (GVHD) ... or primary refractory disease with a circulating blast count of no more than 10,000/mm^3 (Arms A or C only) Acute myeloid ...

    Clinical Trial last updated 06/06/2016 - 2:55pm.

  3. CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

    ... therapy, who will receive a peripheral blood stem cell transplant . A malignant disease includes the following: Chronic ... Leukemia (CML) in chronic phase, accelerated phase or blast crisis; Acute Myelogenous Leukemia ... this study is to learn more about the effects of CD34+ stem cell selection on graft versus host disease (GVHD) in children, adolescents and ...

    Clinical Trial last updated 05/03/2016 - 10:47am.

  4. Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy

    ... RATIONALE: A peripheral stem cell transplant may be able to replace blood-forming cells that were ... leukemia Chronic myelogenous leukemia all types except blast crisis (note treated blast crisis in chronic phase is eligible). ...

    Clinical Trial last updated 05/02/2016 - 2:20pm.

  5. Growth Factors

    ... Red Cell Growth Factor Red cell growth ... white cell growth factors can increase the growth of blast cells in patients with high-risk MDS. This can be a serious problem. For ...

    Topic section last updated 04/06/2016 - 12:37pm.

  6. Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies (AB-CliniMACs)

    ... is a single arm pilot study for patients using α/β T cell -depleted PSCT in with alternative donor sources with hematologic ... leukemia Disease status: chronic phase, accelerated phase or blast crisis now in second chronic phase. Mixed lineage or biphenotypic ...

    Clinical Trial last updated 06/06/2016 - 3:10pm.

  7. Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies (AB-CliniMACs)

    ... is a single arm pilot study for patients using α/β T cell -depleted PSCT in with alternative donor sources with hematologic ... leukemia Disease status: chronic phase, accelerated phase or blast crisis now in second chronic phase. Mixed lineage or biphenotypic ...

    Clinical Trial last updated 06/03/2016 - 2:45pm.

  8. Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation

    ... help the immune system recover faster following a stem cell transplant . Blood stem cells are very young blood cells that ... second chronic phase, or in CR after accelerated phase or blast crisis. Non-Hodgkins lymphoma with chemo responsive disease in any of ...

    Clinical Trial last updated 04/29/2016 - 1:11pm.

  9. Inducible Regulatory T Cells (iTregs) in Non-Myeloablative Sibling Donor Peripheral Blood Stem Cell Transplantation

    ... HLA -identical sibling donor peripheral blood stem cell (PBSC) transplantation for the treatment of a high risk malignancy. Up to ... of ≥15%. Chronic myelogenous leukemia all types except blast crisis (note treated blast crisis in chronic phase is eligible) ...

    Clinical Trial last updated 04/29/2016 - 1:48pm.

  10. Intra-Osseous Co-Transplant of UCB and hMSC

    ... donor umbilical cord blood and mesenchymal stromal cell co-transplant in treating patients with hematologic malignancies. Giving ... leukemia (CML) in second chronic phase after accelerated or blast crisis; blast crisis defined as: Blast count ≥ 20% in the ...

    Clinical Trial last updated 05/02/2016 - 11:15am.