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  1. Treating Higher-Risk Myelodysplastic Syndromes

    ... System, which is known as WPSS. IPSS takes into account blast percentage in the bone marrow , any chromosomal abnormalities seen ... of MDS subtypes and whether the patient is dependent on red cell transfusions. In the WPSS, a score of three or above is considered ...

    Interview last updated 05/18/2012 - 1:55pm.

  2. Acute Myeloid Leukemia (AML)

    ... of every 100 white blood cells in the bone marrow is a blast cell . AML is the most common acute leukemia affecting adults, with about ...

    Topic section last updated 07/07/2016 - 3:15pm.

  3. Clone of Myelodysplastic Syndromes (MDS)

    ... Blast Counts Blasts are very young or ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia . ...

    Page last updated 04/05/2016 - 3:56pm.

  4. Infectious complications in patients with myelodysplastic syndromes: a review of the literature with emphasis on patients treated with 5-azacitidine

    ... (MDS) are oligo-clonal diseases of the hematopoietic stem cell compartment resulting in peripheral cytopenias and a tendency of ... (IPSS) was the first to include - beside medullary blast count and karyotype - the number of cytopenias and thereby indirectly ...

    Research Article last updated 04/14/2017 - 10:41am.

  5. Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes (h-MDS)

    ... were recruited. h-MDS patients had lower PB white blood cell and blast counts, and lower BM blast percentages, than those with NH-MDS. h-MDS was ...

    Research Article last updated 09/19/2016 - 11:07am.

  6. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... syndromes (MDS) is allogeneic hematopoietic stem cell transplantation (alloSCT). As alloSCT confers both a short-term mortality ... of clone size in patients with MDS without increased blast proportion is poorly studied, and it is also not yet known whether ...

    Research Article last updated 04/29/2016 - 10:22am.

  7. Hematopoietic Cell Transplantation for Myelodysplastic Syndromes

    ... Allogeneic hematopoietic cell transplantation (HCT) offers the only potential cure for patients with ... more appropriate for those with lower-risk disease. A high blast burden at the time of HCT increases the risk of subsequent relapse; ...

    Research Article last updated 10/06/2016 - 1:59pm.

  8. Growth Factors

    ... but they do not replace immunosuppressive therapy. Red cell growth factor is called erythropoietin or EPO for short. It is a ... white cell growth factors can increase the growth of blast cells in patients with high-risk MDS. This can be a serious problem. For ...

    Page last updated 01/20/2015 - 4:43pm.

  9. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... eligible for, or opted not to participate in allogenic stem cell transplantation h. Off all other treatments for MDS (including AZA ... diagnosed with AML (defined as a bone marrow blast percentage of >30%) d.         Suitable candidate to receive ...

    Clinical Trial last updated 05/04/2018 - 3:53pm.

  10. A Remarkable Response in a Clinical Trial

    ... (MDS), a disease that has no cure except for a stem cell transplant . Because I was in my mid-70s, a bone marrow transplant ... and elated. When I’d arrived at MD Anderson, my blast count was at 30%, extremely high and well into to the AML range, which ...

    Patient Chronicle last updated 04/26/2018 - 12:46pm.