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  1. Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes

    ... Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment ... two groups (P = 0.500). However, for patients with a high blast count (>5 % of bone marrow at the time of diagnosis), ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Myelodysplastic Syndromes (MDS)

    ... Blast Counts Blasts are very young or ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia . ...

    Page last updated 07/20/2018 - 5:15pm.

  3. Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes: Improved outcomes for de novo disease.

    ... Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes : Improved ... p = 0.02). There was no correlation of survival with blast count at diagnosis, IPSS score, cytogenetic abnormality, donor type, or ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Myelodysplastic syndromes in children: where are we today?

    ... and Down syndrome-associated myeloid leukemia.Although the blast count plays a central role in differentiating leukemias from MDSs, it is ... when detected make diagnosis easy. Hematopoietic stem cell transplant is the treatment of choice, while newer agents have shown ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes.

    ... (MDS) fare poorly following allogeneic hematopoietic cell transplant (HCT). We report prospective phase II study results of 29 ... and blasts <10%). Marrow cellularity (P<0.0001) and blast% (P=0.03) were reduced. Toxicities were acceptable, with transient ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. MDS - Basics

    ... Blast Counts Blasts are very young ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia ...

    Topic section last updated 06/12/2018 - 12:47pm.

  7. An Unusual Route to Diagnosis

    ... , hematocrit , and my red and white blood cell count. She ran several tests, and I had a liver biopsy.  After a ... doctors consulted with each other it was determined that my blast count (young, immature white blood cells was better than expected so we ...

    Patient Chronicle last updated 04/26/2018 - 12:12pm.

  8. Luspatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes (PACE-MDS): a multicentre, open-label phase 2 dose-finding study with long-term extension study

    ... chronic myelomonocytic leukaemia ( white blood cell count <13 000/μL), and had anaemia with or without red blood ... in one patient each: myalgia (one [2%]), increased blast cell count (one [2%]), and general physical health deterioration (one ...

    Research Article last updated 09/18/2017 - 1:38pm.

  9. MDS - Treatment (OLD)

    ... change over time. As blood counts go lower and bone marrow blast counts rise, your doctor will discuss other treatment options. ... May or may not need blood transfusions, depending on blood cell counts Have a low or intermediate-1 risk IPSS score, which is between ...

    Topic section last updated 07/20/2018 - 5:15pm.

  10. Types

    ... Considered the mildest category. MDS is limited to one cell line. There is little dysplasia. Has 3 subtypes: ... treatment of the three primary variables for assessing MDS: blast percentages, cytopenias, and type and degree of chromosomal abnormalities ...

    Topic section last updated 07/20/2018 - 5:15pm.