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  1. Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

    ... detectable CH50 activity (CH50>10%) (p=0.004), elevated bilirubin levels (p<0.0001), and the need for transfusions (p=0.034). This ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. A Phase II Study of SGI-110 in Philadelphia-Negative Myeloproliferative Neoplasms

    ... have normal organ function as defined below: Total bilirubin < or = 1.5 x institutional upper limit of normal unless ...

    Clinical Trial last updated 05/14/2018 - 2:02pm.

  3. A Phase II Study of the Combination of Azacitidine and Pembrolizumab for Patients with Myelodysplastic Syndrome (MDS)

    ... be calculated per institutional standard. Serum total bilirubin 1.5 ULN. AST (SGOT) and ALT (SGPT) Female subject of ...

    Clinical Trial last updated 05/14/2018 - 1:57pm.

  4. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... to appropriate therapy h.         Total bilirubin ≥ 1.5 mg/dL not related to hemolysis or Gilbert’s ...

    Clinical Trial last updated 05/04/2018 - 3:53pm.

  5. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... (MUGA) may be substituted for LVEF. Hepatic: Total bilirubin < 3.0 x the upper limit of normal (ULN) for age (patients who ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  6. FDA approves new drug for relapsed or refractory AML

    ... of patients were nausea, vomiting, diarrhea, elevated bilirubin , and decreased appetite. Differentiation syndrome occurred in 14% ...

    Article last updated 08/30/2017 - 8:30am.

  7. A retrospective study of paroxysmal nocturnal hemoglobinuria in pediatric and adolescent patients

    ... first group of patients had higher levels of LDH, total bilirubin and absolute reticulocyte count and a bigger PNH ...

    Research Article last updated 05/02/2017 - 10:42am.

  8. A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Hematologic Malignancies with an IDH1 Mutation

    ... considered due to leukemic disease and serum total bilirubin ≤1.5 x upper limit of normal (ULN), unless considered due to ...

    Clinical Trial last updated 02/22/2017 - 11:21am.

  9. Interviews with the Experts: Hemolysis in PNH and Beyond

    ... – yellowness of the eyes and skin --because of bilirubin , which is a byproduct of red cell destruction. Some patients ...

    Interview last updated 08/31/2016 - 8:40am.

  10. AML Therapy With Irradiated Allogeneic Cells

    ... of AML in patient >= 60 years old Total bilirubin =< 1.5 times upper limit of normal (ULN) institutional limits ... of patient adverse effects or poor outcomes Total bilirubin < 1.5 times upper limit of normal (ULN) institutional limits (unless ...

    Clinical Trial last updated 06/13/2016 - 3:14pm.