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  1. Pure Red Cell Aplasia (PRCA)

    ... cases have been reported worldwide. The severity of the disease varies by patient. Relation to bone marrow failure ... cause of most cases of PRCA is most recently thought to be autoimmune in nature. Doctors think it is caused by a mistaken attack by the ...

    Topic section last updated 07/07/2016 - 3:14pm.

  2. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... cells by spinal fluid will be eligible Known active autoimmune disorder Known to be human immunodeficiency virus (HIV)-positive ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.

  3. Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

    ... inhibitor (CNI)-free strategies for Graft-versus-Host Disease (GVHD) prophylaxis to standard tacrolimus and methotrexate ... year after transplantation History of uncontrolled autoimmune disease or on active treatment Patients with prior ...

    Clinical Trial last updated 06/06/2016 - 1:36pm.

  4. Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCT (RIC HSCT NMD)

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... syndrome IPEX syndrome Chediak -Higashi Syndrome Autoimmune Lymphoproliferative Syndrome (ALPS) Hemophagocytic ...

    Clinical Trial last updated 06/13/2016 - 2:18pm.

  5. An Open-label Study of Lirilumab (BMS-986015) in Combination With 5-azacytidine (Vidaza) for the Treatment of Patients With Refractory/ Relapsed Acute Myeloid Leukemia

    ... to learn if the drug combination can help to control the disease. The safety of the drug combination will also be studied. ... Patients with a known history of any of the following autoimmune diseases are excluded: (a) patients with a history of inflammatory ...

    Clinical Trial last updated 06/06/2016 - 1:26pm.

  6. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... Anastasios Karadimitris Aplastic anemia is a disease where the patients’ immune system attacks his or her own bone ... it has been believed that PNH should be considered an autoimmune disease for a different reason—because it occurs commonly in ...

    Research Review last updated 05/02/2016 - 9:26am.

  7. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... from leukapheresis or G-CSF therapy (e.g., active autoimmune disease , sickle cell trait, symptomatic coronary artery disease ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  8. Role of microRNAs in Aplastic Anemia

    ... healthy people and from patients with MDS or sickle cell disease. Key findings: miRNAs were downregulated, meaning that ... the role of these miRNAs in the more general development of autoimmune diseases.   ...

    Research Review last updated 05/02/2016 - 9:15am.

  9. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... normal practice for such subject.     History of autoimmune disorder (e.g. hepatitis)     Hypersensitivity to interferon ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.

  10. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... may help stop a side effect called Graft-Versus-Host Disease (GVHD) . Some studies have been done with CliniMACS, but the Food ... CD40 ligand deficiency, or ALPS, as well as refractory autoimmune cytopenias, PNH, metabolic storage diseases or heavily transfused ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.