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  1. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disease that has been investigated for over one century and has revealed unique ... that expansion of the PNH clone results from T-cell-mediated auto-immune damage to hematopoietic stem cells , with the GPI molecule ...

    Research Article last updated 06/07/2016 - 10:56am.

  2. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... Myelodysplastic Syndromes (MDS) and autoimmune disorders (AD): Cause or consequence? ... with both MDS and AD – other than trisomy 8 in Behcet’s disease. It is unknown if AD have an impact on overall survival in MDS ...

    Research Review last updated 05/02/2016 - 9:18am.

  3. AAMDSIF Summer Fellowship Grant Program

    ... is a bone marrow failure disorder, and it is a devastating disease that can have a rapid onset with an often unclear cause. Aplastic anemia has been shown to have a strong association with autoimmune and inflammatory disorders, in which immune cells attack normal ...

    Page last updated 05/17/2017 - 1:29pm.

  4. Immunosuppression and Stem Cell Transplantation – How Are These Treatments Chosen?

    ... 80% of aplastic anemia patients, the underlying cause of the disease is immunologic – it’s an autoimmune disease . As with other autoimmune diseases like multiple ...

    Interview last updated 07/15/2015 - 10:19am.

  5. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... Anastasios Karadimitris Aplastic anemia is a disease where the patients’ immune system attacks his or her own bone ... it has been believed that PNH should be considered an autoimmune disease for a different reason—because it occurs commonly in ...

    Research Review last updated 05/02/2016 - 9:26am.

  6. Scientific Symposium Co-Chair Richard Stone, MD Discusses Progress and New Directions in Bone Marrow Failure Disease Research

    ... two years is so important to bone marrow failure disease research? This symposium brings together world leaders in basic, ... example, we previously thought of aplastic anemia as an autoimmune disease , which it certainly is. But there are other reasons for ...

    Interview last updated 04/29/2014 - 12:01pm.

  7. Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

    ... inhibitor (CNI)-free strategies for Graft-versus-Host Disease (GVHD) prophylaxis to standard tacrolimus and methotrexate ... year after transplantation History of uncontrolled autoimmune disease or on active treatment Patients with prior ...

    Clinical Trial last updated 06/06/2016 - 1:36pm.

  8. Dr. Kasiani Myers: Acquired and Inheirited Bone Marrow Failure

    ... between acquired and inherited bone marrow failure disease? Hereditary bone marrow failure results from a genetic ... aplastic anemia is thought to be primarily an autoimmune, or immune-mediated disorder. So a trigger of some kind sets off the ...

    Interview last updated 02/14/2017 - 8:34am.

  9. Anastasios Karadimitris, MD, PhD

    ... anemia (IAA). Both disorders are considered to have an autoimmune mechanism involving auto-reactive T cells targeting hematopoietic ... Haemoglobinuria (PNH) is a bone marrow failure  disease in which there is a severe depletion of haematopoietic stem cells ...

    Grant Recipient last updated 03/07/2017 - 9:50am.

  10. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... cells by spinal fluid will be eligible Known active autoimmune disorder Known to be human immunodeficiency virus (HIV)-positive ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.