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  1. Molecular and genetic features of myelodysplastic syndromes.

    ... hematopoiesis in MDS has been the varying degrees of apoptosis of the hematopoietic precursors and their progeny. A variety of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Decitabine in the treatment of myelodysplastic syndromes.

    ... genes, leading to cellular differentiation and/or apoptosis . Decitabine is a cytidine analogue that has activity as ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Therapeutic modalities for patients with lower-risk myelodysplastic syndromes: current options and future directions.

    ... aimed at promoting hematopoiesis , inhibiting apoptosis , and reducing the risk of transformation to acute myeloid ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Myelodysplastic syndromes: an update on molecular pathology.

    ... is a significant increase in programmed cell death ( apoptosis ) in haematopoietic cells. Furthermore, altered responses in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

    ... CONTEXT: Critically short telomeres produce apoptosis , cell senescence, and chromosomal instability in tissue culture ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.

    ... suppressed T-cell proliferation and induced T-cell apoptosis in allogeneic cocultures. When fresh bone marrow samples from ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Lenalidomide for treatment of myelodysplastic syndromes: current status and future directions.

    ... cdc25c, thereby promoting selective G2 arrest and apoptosis . In non-del(5q) patients, lenalidomide enhances ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. The molecular pathogenesis of myelodysplastic syndromes.

    ... regulation, microenvironment interactions, regulation of apoptosis and oxidative damage/DNA repair may all play an important ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromes

    ... MAPK over-activation may contribute to the increasing apoptosis of marrow cells, a phenomenon commonly observed in MDS, and lead ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Immunomodulatory Drugs: New Options for the Treatment of Myelodysplastic Syndromes

    ... and antiangiogenic activities, and they also induce the apoptosis of neoplastic cells. Thalidomide and its derivative ...

    Research Article last updated 07/20/2018 - 5:14pm.