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  1. Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy

    ... kinase pathways that induces mitotic arrest and apoptosis in neoplastic cells, while sparing normal cells. Our purpose is ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes

    ... division and preventing from premature senescence and apoptosis . The rate-limiting component of telomerase is human telomerase ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... Subsequent to P53 activation, erythroid cell apoptosis and ineffective erythropoiesis occur. Other pathogenetic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Key clinical observations after 5-azacytidine and decitabine treatment of myelodysplastic syndromes suggest practical solutions for better outcomes

    ... of p53, thus circumventing a basis for resistance to apoptosis -based DNA-damaging therapy. That responses cut across the chaotic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Myelodysplastic Syndromes (MDS) and autoimmune disorders (AD): Cause or consequence?

    ... factor-(TNF)-α and interferon (IF)-γ triggers apoptosis of myeloid precursor cells leading to cytopenias. Impaired ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... DNA damage response and result in cellular senescence or apoptosis . In the setting of failed checkpoint mechanisms, such DNA-protein ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.

    ... tool. The loss of GMPs is likely due to increased apoptosis and increased phagocytosis, the latter due to the up-regulation ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. The different immunoregulatory functions of mesenchymal stem cells in patients with low-risk or high-risk myelodysplastic syndromes

    ... with the presence of increased TGF-β1, higher apoptosis , higher immunosuppressive rate and a poor ability of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Molecular and genetic features of myelodysplastic syndromes.

    ... hematopoiesis in MDS has been the varying degrees of apoptosis of the hematopoietic precursors and their progeny. A variety of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Decitabine in the treatment of myelodysplastic syndromes.

    ... genes, leading to cellular differentiation and/or apoptosis . Decitabine is a cytidine analogue that has activity as ...

    Research Article last updated 07/20/2018 - 5:14pm.