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  1. Unveiling the paradoxical nature of myelodysplastic syndromes (MDS): Why hypercellular marrow strongly favors accelerated apoptosis.

    ... portion of the developing hematopoietic cells by apoptosis . The present study aimed to delineate the exact mechanistic ... between the bone marrow hypercellularity and the accelerated apoptosis in an N-ethyl-N-nitrosourea (ENU)-induced experimental MDS mouse ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia.

    ... Disordered stem cell epigenetics and apoptosis -regulating mechanisms contribute essentially to the pathogenesis ... to secondary acute myeloid leukemia (AML). Expression of apoptosis-mediators FAS (CD95) and DAPK1 the latter being also known for its ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Methylation of the p73 gene in patients with myelodysplastic syndromes: correlations with apoptosis and prognosis

    ... we analyzed p73 expression using real-time PCR. The apoptosis of BM cells was examined by flow cytometry . The ... by methylation (p  =  0.032). Although the level of apoptosis in the BM samples of the methylated group was not significantly lower ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes

    ... the role of miR-378 in the proliferation and apoptosis of SKM-1 cells, an acute myeloid leukemia cell line established ... in SKM-1 cells interfered with proliferation via inducing apoptosis and G0/G1-phase cell cycle arrest, and suppressive effect of miR-378 ...

    Research Article last updated 11/02/2016 - 9:31am.

  5. A novel histone deacetylase inhibitor Chidamide induces G0/G1 arrest and apoptosis in myelodysplastic syndromes

    ... P21 protein expression. Meanwhile,it also induced cell apoptosis by down-regulating Bcl-2 and up-regulating cleaved Caspase-3 and ...

    Research Article last updated 11/02/2016 - 9:39am.

  6. The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes.

    ... of tumor necrosis factor α (TNFα) and up-regulation of apoptosis in the marrow. In contrast, marrow cells in advanced MDS are typically resistant to TNFα-induced apoptosis but are rendered apoptosis-sensitive on coculture with stroma. The ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. The myelodysplastic syndrome as a prototypical epigenetic disease.

    ... aberrant differentiation resulting in a high rate of apoptosis and eventual symptoms related to bone marrow failure . ... growth-controlling genes that seem to tip the proliferation/apoptosis balance and result in the development of acute myelogenous ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Anemia as the Main Manifestation of Myelodysplastic Syndromes

    ... to ineffective erythropoiesis, with a high degree of apoptosis of marrow erythroid progenitors. These progenitors show ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. The complex pathophysiology of acquired aplastic anemia

    ... and tumor growth factor -beta (TGF-β), induce apoptosis of HSPCs, constituting a consistent and defining feature of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... and by the occurrence of intramedullary apoptosis . During the past decade, the identification of key genetic and ...

    Research Article last updated 07/20/2018 - 5:15pm.