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  1. Somatic mutations identify a sub-group of aplastic anemia patients that progress to myelodysplastic syndrome

    ... Aplastic anemia (AA) is a heterogeneous disorder. The distinction between acquired ... stored BM and constitutional DNA. We excluded Fanconi anemia , mutations of telomere maintenance, and a family history of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution

    ... First line therapy of aplastic anemia with high dose cyclophosphamide causes toxicity and ... Bone Marrow Diseases:  aplastic anemia ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Alternative donor HSCT in refractory acquired aplastic anemia - Prevention of graft rejection and graft versus host disease by immunoablative conditioning and graft manipulation

    ... donor HSCT in refractory acquired aplastic anemia - Prevention of graft rejection and graft versus host disease by ... renal failure (resulting from microangiopathic hemolytic anemia ) and disseminated aspergillosis. Early alternative donor HSCT can ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... Acquired aplastic anemia (aAA) is a nonmalignant disease caused by autoimmune destruction of ... Bone Marrow Diseases:  aplastic anemia ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Bone marrow mesenchymal stem cells from aplastic anemia patients preserve functional and immune properties and do not contribute to the pathogenesis of the disease

    ... Aplastic anemia is a life-threatening bone marrow failure disorder ... and marrow hipoplasia. The majority of aplastic anemia cases remain idiopathic , and hematopoietic stem cell deficiency ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation.

    ... A proportion of patients with aplastic anemia who are treated with immunosuppressive therapy develop clonal ... including myelodysplastic syndrome (post-aplastic anemia myelodysplastic syndrome). Many will proceed to allogeneic ... We identified 123 patients with post-aplastic anemia myelodysplastic syndrome who from 1991 through 2011 underwent ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Relapse of aplastic anemia in children after immunosuppressive therapy: a report from the Japan Childhood Aplastic Anemia Study Group.

    ... Although the therapeutic outcome for acquired aplastic anemia has improved markedly with the introduction of immunosuppressive ... therapy. However, detailed analyses of relapses in aplastic anemia children are limited. Design and Methods. We previously conducted two ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes.

    ... Although aplastic anemia and myelodysplasia have been extensively investigated, little is ... We compared plasma soluble cytokines in 33 aplastic anemia, 57 myelodysplasia patients, and 48 healthy controls. High levels of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Aplastic Anemia & MDS International Foundation: Bone marrow failure disease scientific symposium 2012

    ... or immunosuppression as first therapy in severe aplastic anemia is currently based on age and availability of a histocompatible ... have been implicated in clinical diseases such as aplastic anemia, pulmonary fibrosis , cirrhosis and cancer development. The ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Etiology and survival of aplastic anemia: a study based on clinical investigation

    ... BACKGROUND: Management of aplastic anemia is etiology driven, whether constitutional or acquired. Age, ... disease also play crucial role in the survival of aplastic anemia. Since, inadequate data are available from India, the present study was ...

    Research Article last updated 07/20/2018 - 5:14pm.