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  1. Myelodysplastic syndromes: Contemporary review and how we treat

    ... syndromes (MDS) are a heterogeneous group of clonal stem cell disorders with an inherent tendency for leukemic transformation. ... lenalidomide for MDS with isolated del(5q). To date, allogeneic stem cell transplant (ASCT) remains the only treatment option ...

    Research Article last updated 04/29/2016 - 1:05pm.

  2. Personalized medicine for MDS

    ... be considered for a more intensive treatment, such as allogeneic stem cell transplant , earlier in the course of disease.  This personalized ...

    Research Review last updated 05/02/2016 - 9:44am.

  3. Alternative Donor Transplantation with High-Dose Post-Transplantation Cyclophosphamide for Refractory Severe Aplastic Anemia

    ... anemia (SAA) is a life-threatening hematopoietic stem cell disorder that is treated with bone marrow transplantation ... Between July 2011 and August 2016, 16 patients underwent allogeneic (allo) BMT for refractory SAA from 13 haploidentical donors and 3 ...

    Research Article last updated 01/24/2017 - 10:04am.

  4. Recent developments in bone marrow transplants

    ... Celgene) maintenance following autologous hematopoietic stem cell transplantation improved survival outcomes without increasing the ... with poor outcomes and shorter OS in patients undergoing allogeneic HSCT for myelodysplastic syndrome or acute myeloid leukemia. ...

    Article last updated 11/16/2016 - 2:56pm.

  5. Comparable outcomes between younger (⩽40 years) and older (>40 years) adult patients with severe aplastic anemia after HLA-matched sibling stem cell transplantation using fludarabine-based conditioning

    ... Allogeneic stem cell transplantation from HLA -matched siblings (MSD-SCT) for ...

    Research Article last updated 11/28/2016 - 9:28am.

  6. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... How did the idea to study a particular type of stem cell transplant originate? The idea for the study in question is ... of prior research that was focused on ways to offer safe allogeneic stem cell transplants using alternative donors for patients who lack ...

    Interview last updated 10/04/2017 - 1:36pm.

  7. CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease

    ... are offering to treat the donor peripheral blood stem cells in the hope that it will make it less likely for the patient who ... Some patients on this study will receive an allogeneic stem cell transplant (AlloSCT) from a matched related donor ...

    Clinical Trial last updated 04/27/2016 - 8:55am.

  8. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... (OS) separately in the 2 arms at 1 year post-hematopoietic stem cell transplantation (HSCT). ... (MFI) > 1000 by solid phase immunoassay). Prior allogeneic stem cell transplant . Prior solid organ transplant. ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  9. CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease

    ... in children, adolescents and young adults receiving an allogeneic peripheral blood ... Hemoglobinopathies per protocol. Requirement for CD34+ stem cell selection for a second infusion of stem cells following an ...

    Clinical Trial last updated 06/13/2016 - 2:06pm.

  10. Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children

    ... how well T cell depleted donor peripheral blood stem cell transplant works in preventing graft-versus-host disease in ... Patients who are considered appropriate candidates for allogeneic hematopoietic stem cell transplantation and have one of the ...

    Clinical Trial last updated 06/13/2016 - 2:29pm.