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  1. Comparison of Rabbit Antithymocyte Globulin (R-ATG) and Jurkat Cell-Reactive Anti-T Lymphocyte Globulin (ATG-F) as a First-line Treatment for Children with Aplastic Anemia

    ... globulin (R-ATG) and Jurkat cell-reactive anti- T lymphocyte globulin (ATG-F) in the treatment of childhood aplastic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. A Marked Decrease in CD4-Positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-Associated Aplastic Anemia.

    ... Primary Author:  Ikeda T Author(s):  ... especially CD4 T-lymphocytopenia. Although the total lymphocyte counts rose as the patient recovered from hepatitis, this was ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... deficient progenitor cells, a novel T lymphocyte enrichment culture assay with proaerolysin selection to expand glycosylphosphatidylinositol-anchor deficient T lymphocytes , and PIG-A gene sequencing assays to identify and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... characterized by development and expansion of self-reactive T cells. These T cells cause continuous destruction of hematopoietic stem ... AA was reproduced in animals, including mouse lymphocyte infusion models, which are used to study further etiology ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. STAT3-mutations indicate the presence of subclinical T cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.

    ... Large granular lymphocyte leukemia (LGL) is often associated with immune cytopenias and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: results of a bone marrow failure consortium study.

    ... Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exhibit seroreactivity against a human ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Paroxysmal nocturnal hemoglobinuria

    ... Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exhibit seroreactivity against a human ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Immune markers of disease severity and treatment response in pediatric acquired aplastic anemia

    ... with aplastic anemia (AA) and explore PNH-status, T-regulatory and NK-cell frequency as potential markers of clinical response. ... 2/6 PNH(neg) patients had a CR and 4/6 had a PR. Lymphocyte subset immunophenotyping revealed that T-regulatory cells ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes

    ... Lastly, the capacity of MDS-MSCs to inhibit T lymphocyte activation and proliferation was impaired in vitro. These ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. A combination of fludarabine, half-dose cyclophosphamide, and anti-thymocyte globulin is an effective conditioning regimen before allogeneic stem cell transplantation for aplastic anemia

    ... Ashizawa M, Akahoshi Y, Nakano H, Ugai T, Wada H, Yamasaki R, Ishihara Y, Kawamura K, Sakamoto K, Sato M, Terasako K, ... . One became transfusion-independent after donor lymphocyte infusion, but continues to exhibit MC. The other regained ...

    Research Article last updated 07/20/2018 - 5:15pm.