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  1. Relapse of aplastic anemia in children after immunosuppressive therapy: a report from the Japan Childhood Aplastic Anemia Study Group.

    ... Primary Author:  Kamio T Author(s):  ... immunosuppressive therapy received hematopoietic stem cell transplantation and five are alive. Eleven patients directly underwent ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Clustering of comorbidities is related to age and sex and impacts clinical outcome in myelodysplastic syndromes

    ... Bammer C, Sperr WR, Kemmler G, Wimazal F, Nösslinger T, Schönmetzler A, Krieger O, Pfeilstöcker M, Valent P, Stauder R ... MATERIAL AND METHODS: The hematopoietic cell transplantation-comorbidity index (HCT-CI) was assessed in 616 ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Pediatric myelodysplastic syndromes: they do exist!

    ... Primary Author:  Glaubach T Author(s):  ... bone marrow with dysplasia in ≥1 blood cell lineages. MDS frequently evolves to secondary acute myeloid leukemia with ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage specific expansion and harbor genetic and epigenetic alterations.

    ... Vogler TO, Ben-Neriah S, Schinke C, Tamari R, Yu Y, Bhagat T, Bhattacharya S, Barreyro L, Heuck C, Mo Y, Parekh S, McMahon C, Pellagatti ... Even though hematopoietic stem cell (HSC) dysfunction is presumed in MDS, the exact nature of quantitative ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria

    ... Many proteins, including CD55 and CD59, are anchored to the cell by GPI. Loss of CD55 and CD59 on erythrocytes causes complement-mediated ... identified a single nonsense PIGA mutation , c.1234C>T, which predicts p.Arg412(∗). This variant segregated with disease and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Successful Use of Eculizumab in a Pediatric Patient Treated for Paroxysmal Nocturnal Hemoglobinuria

    ... Primary Author:  Bauters T Author(s):  ... debilitating life-threatening clonal hematopoietic stem cell disease. The clinical manifestations of PNH are usually seen in adulthood ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

    ... Primary Author:  Graubert T Author(s):  ... Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy -resistant secondary ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS Original Publication ... In cell and animal models, telomere erosion promotes chromosomal ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Retrospective survey on the prevalence and outcome of prior autoimmune diseases in patients with aplastic anemia reported to the registry of the European group for blood and marrow transplantation.

    ... S, Marsh J, Tridello G, Rovò A, Maury S, Montante B, Masszi T, Van Lint MT, Afanasyev B, Iriondo Atienza A, Bierings M, Carbone C, Doubek ... therapy (IST), 8 patients underwent hematopoietic stem cell transplantation (HSCT) - 6 as first-line therapy and 2 after failure of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    ... Williams DA, Bennett C, Bertuch A, Bessler M, Coates T, Corey S, Dror Y, Huang J, Lipton J, Olson TS, Reiss UM, Rogers ZR, Sieff C, ... therapy (IST); uniform referral for hematopoietic stem cell transplantation as first line therapy if an HLA -identical sibling ...

    Research Article last updated 07/20/2018 - 5:15pm.