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  1. Abatacept Reduced Intensity for Non-Malignant Diseases (Aba NMD)

    ... Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only viable cure for children who ... from graft versus host disease (GVHD), driven by donor T cells recognizing and reacting against disparate host antigens. This trial is ...

    Clinical Trial last updated 04/27/2016 - 2:40pm.

  2. UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep

    ... high risk CR1 as evidenced by high risk cytogenetics (e.g. t(9;22), t(1;19),t(4;11), other mixed-lineage leukemia (MLL) rearrangements, ... lymphoma in CR2 or subsequent CR Natural killer cell malignancies Chronic myelogenous leukemia (CML): all types except ...

    Clinical Trial last updated 04/29/2016 - 10:06am.

  3. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... PNH seems to be a different type of disease. Here the PNH cell is not attacked because of a molecule it has, but rather, because of ... proteins (such as CD55 and CD59) normally prevent the red cell from being broken down by complement proteins. In a way, PNH could also be ...

    Research Review last updated 05/02/2016 - 9:26am.

  4. Clone of Myelodysplastic Syndromes (MDS)

    ... ? Bone marrow failure occurs when the marrow doesn't produce enough red cells, white cells or platelets, or the blood cells that ... MDS have two things in common: They have a low blood cell count for at least one blood cell type. This is called a cytopenia . ...

    Page last updated 04/05/2016 - 3:56pm.

  5. Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes

    ... monohydrate CTX CYCLO-cell Cycloblastin Cycloblastine Cyclophospham Cyclophosphamid ... Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion Given IV Drug: Fludarabine Phosphate Given IV Other ... T 586 Other: Laboratory Biomarker Analysis Correlative studies Drug: ...

    Clinical Trial last updated 04/27/2016 - 1:17pm.

  6. North American Pediatric Aplastic Anemia Consortium Symposium

    ... to show mild dysplasia and patchy areas of red blood cell , or erythroid, precursors. However, in the absence of an MDS defining ... graft rejection, which is problematic for patients who don’t respond to IST. As donor matching and supportive care within hematopoietic ...

    Page last updated 10/31/2013 - 4:06pm.

  7. Research Retrospective for AA&MDSIF 30th Anniversary - Dr. Neal Young

    ... readily available to most patients, changes in red blood cell transfusion methods have decreased the problem of alloimmunization, ... of the underlying pathophysiology , we really don’t’ understand it in detail. So, empirically, horse ATG remains our best ...

    Interview last updated 05/08/2013 - 2:51pm.

  8. Eltrombopag: Recent Discoveries on Potential New Applications for Aplastic Anemia

    ... in some patients, but also improve white and red blood cell counts. This was a surprising finding, as the drug was really ... trials for aplastic anemia? Originally we weren't that hopeful that eltrombopag would be useful in aplastic anemia, because the ...

    Interview last updated 02/14/2014 - 2:01pm.

  9. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... hemolysis .  In patients a with large PNH red cell population who need aplastic anemia treatment, one thing to do is give ... can be seen in PNH or aplastic anemia, but it doesn’t secure a diagnosis of MDS. ...

    Interview last updated 04/15/2015 - 9:39am.

  10. Veteran Patients

    ... The fact that an exposure is remote in time doesn’t mean it can’t contribute to MDS. A major  epidemiological study ... the 1960s or 1970s, that DNA injury in a bone marrow cell could have made it more likely that MDS would develop later on as a result ...

    Topic section last updated 03/25/2016 - 11:56am.