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  1. Allogenic stem cell transplantation for older patients with AML and MDS

    ... myeloid leukemia (AML). For these patients, allogeneic stem cell transplantation is the only treatment that has demonstrated the ability to ... points. One is that in the older patient, allogeneic stem cell transplantation is feasible with patients experiencing MDS-free survival ... Reviewer Bio:  Aaron T. Gerds, MD, MS ...

    Research Review last updated 05/02/2016 - 9:31am.

  2. Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

    ... MJ, Nichols EM, Hebecker M, Anliker M, Höchsmann B, Simmet T, Csincsi ÁI, Uzonyi B, Pappworth IY, Ricklin D, Lambris JD, Schrezenmeier H, ... (PNH) is characterized by complement-mediated cell lysis due to deficiency of GPI-anchored complement regulators. Blockage of ...

    Research Article last updated 04/29/2016 - 12:58pm.

  3. Inducible Regulatory T Cells (iTregs) in Non-Myeloablative Sibling Donor Peripheral Blood Stem Cell Transplantation

    ... dose to determine the tolerability of inducible regulatory T cells (iTregs) when given to adult patients undergoing non-myeloablative HLA -identical sibling donor peripheral blood stem cell (PBSC) transplantation for the treatment of a high risk malignancy. Up to ...

    Clinical Trial last updated 04/29/2016 - 1:48pm.

  4. Pasireotide in Prevention of GI Toxicity

    ... of the drugs received to prepare for allogeneic stem cell transplant . The study will also evaluate if Pasireotide is effective ... remission, with high risk being defined by the presence of t(4;11) or t(9;22), or those presenting with extreme hyperleukocytosis or ...

    Clinical Trial last updated 06/06/2016 - 10:41am.

  5. Treatments

    ... may not need treatment as long as the condition doesn't get worse. People who have severe aplastic anemia need medical treatment ... marrow failure diseases to help increase red blood cell , white blood cell or platelet counts. ...

    Topic section last updated 04/19/2016 - 3:36pm.

  6. Total Marrow Irradiation for Refractory Acute Leukemia

    ... a donor umbilical cord blood or hematopoietic stem cell transplant helps stop the growth of cancer cells. It may also stop the ... or not in remission (pediatric patients <18 years) T cell leukemia ≥ CR2 Evidence of pre-transplant minimal residual ...

    Clinical Trial last updated 05/02/2016 - 9:22am.

  7. Myelofibrosis (MF)

    ... and chronic inflammation. If the marrow is scarred, it can’t produce blood cells correctly or perform its normal functions. As a result, ... myelofibrosis than younger people. Having another blood cell disorder, like essential thrombocythemia or polycythemia vera, as these ...

    Topic section last updated 07/07/2016 - 3:16pm.

  8. Biting into the Elephant

    ... low. They told us there was something wrong, but they didn’t know what it was. Referring us to a hematologist / oncologist , ... azacitidine (Vidaza®) treatment followed by a stem cell transplant . I received the gift of life from my brother Neal on ...

    Patient Chronicle last updated 06/27/2016 - 2:22pm.

  9. Administration of Donor Multi TAA-Specific T Cells for AML or MDS (ADSPAM)

    ... called multiple tumor-associated antigen (TAA)-specific T cells (a new experimental therapy) to treat patients with acute myeloid ... treatment, including an allogeneic hematopoietic stem cell transplant (HSCT). The investigators have previously used this ...

    Clinical Trial last updated 04/28/2016 - 11:40am.

  10. Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Hematologic Malignancies Undergoing Donor Peripheral Blood Stem Cell Transplant

    ... malignancies undergoing donor peripheral blood stem cell (PBSC) transplant. Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the ... T 586 Other: Laboratory Biomarker Analysis Correlative studies Drug: ...

    Clinical Trial last updated 04/28/2016 - 12:07pm.