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  1. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... from a multipotent hematopoietic stem cell acquiring a PIG-A mutation . Many patients with aplastic anemia and ... deficient T lymphocytes , and PIG-A gene sequencing assays to identify and analyze PIG-A mutations in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria

    Journal Title:  Am J Hum Genet Primary Author:  Johnston JJ Author(s):  Johns...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... cell (HSC) that acquires a somatic mutation in a gene called phosphatidylinositol glycan anchor biosynthesis, class A (PIG-A). The PIG-A gene is required for the first step in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... stem cells due to a mutation in the PIG-A gene leading to a deficiency of GPI-anchored proteins. Lack of two specific ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... disease that results from somatic mutations in the gene encoding PIGA, which is required for biosynthesis of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance

    ... a monogenic disorder due to acquisition of mutations in the gene encoding PIGA, which is required for glycosylphosphatidylinositol (GPI) ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Paroxysmal nocturnal hemoglobinuria

    ... is almost always due to somatic mutations in PIGA, a gene involved in the first step of GPI anchor biosynthesis; however, ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... the cells from being attacked by the complement system. The gene in charge of making this protective shield is called PIG-A. ...

    Page last updated 07/20/2018 - 5:15pm.

  9. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... mutations in the Phosphatidylinositol Glycan class A (PIG-A) gene in the hematopoietic stem cells (HSC) of patients. The presence of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... in the X-linked phosphatidylinositol glycan class A (PIG-A) gene, which impairs the membrane expression on affected blood cells of a number ...

    Research Article last updated 07/20/2018 - 5:15pm.