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  1. Diagnostic tools in the indications for allogeneic stem cell transplantation in myelodysplastic syndromes.

    ... indications for SCT in MDS remains a difficult task. The International Prognostic Scoring System (IPSS) serves as a guideline for therapeutic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.

    ... of myelodysplastic syndromes (MDS), including the International Prognostic Scoring System (IPSS), do not fully reflect the molecular heterogeneity of the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Current therapeutic approaches for patients with myelodysplastic syndromes.

    ... patients' specific clinical features, predominantly their prognostic subgroups, age and performance status. Guidelines for management of ... in the US and in other countries. For lower risk disease (International Prognostic Scoring System Low and Intermediate-1) therapy is ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial.

    ... of any French-American-British (FAB) subtype and an International Prognostic Scoring System (IPSS) score > or = 0.5. The primary end point was ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes.

    ... consisting of 10 microRNAs was closely associated with International Prognostic Scoring System (IPSS) risk category permitting discrimination ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Differences in community and academic practice patterns for newly diagnosed myelodysplastic syndromes (MDS) patients

    ... with location of treatment (community or academic), prognostic risk category, and patient age. METHODS: The adults in ... (supportive, active, and transplant) were stratified by the international prognostic scoring system (IPSS) and the revised-IPSS (IPSS-R), ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic Syndromes

    ... BCR are commonly found in MDS and might confer important prognostic and therapeutic effect. PATIENTS AND METHODS: Cytogenetic, ... with poor risk cytogenetics, defined according to the International Prognostic Scoring System, which was not altered by new ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. A Phase 1 Study of Oral ARRY-614, a p38 MAPK/Tie2 Dual Inhibitor, in Patients with Low or Intermediate 1 Risk Myelodysplastic Syndromes

    ... Tie2, was conducted in patients with low or intermediate-1 International Prognostic Scoring System risk MDS to evaluate safety, pharmacokinetics (PK), ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. High-risk myelodysplastic syndromes: chemotherapy, transplantation, and beyond.

    ... with considerable nonrelapse mortality and morbidity. The International Prognostic Scoring System, despite its confines, remains a widely used tool ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Enhancing survival outcomes in the management of patients with higher-risk myelodysplastic syndromes.

    ... intermediate-2 or high-risk disease as classified by the International Prognostic Scoring System (IPSS). These patients represent 29% of the MDS ...

    Research Article last updated 07/20/2018 - 5:14pm.