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  1. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... (UPD, 7%). Remarkably, lesions involving the HLA locus suggestive of clonal immune escape were found in 3/93 patients ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies

    ... (HSCT) from Human Leukocyte Antigen ( HLA )-mismatched related donors for children and young adults with ... Available related donor who is mismatched at ≥ 2 HLA alleles Exclusion Criteria:  Available HLA -identical related donor HIV positive Active uncontrolled ...

    Clinical Trial last updated 04/29/2016 - 10:59am.

  3. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    ... stem cell transplantation as first line therapy if an HLA -identical sibling is identified; the use of first-line IST containing ... globulin and cyclosporine A (CSA) if an HLA-identical sibling donor is not identified; supportive care ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. A combination of fludarabine, half-dose cyclophosphamide, and anti-thymocyte globulin is an effective conditioning regimen before allogeneic stem cell transplantation for aplastic anemia

    ... chimerism. Two patients who received a graft from an HLA -matched donor subsequently developed mixed chimerism (MC) associated ... However, subsequent MC may be observed, especially after HLA-matched HSCT. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Impact of Azacitidine Before Allogeneic Stem-Cell Transplantation for Myelodysplastic Syndromes: A Study by the Societe Francaise de Greffe de Moelle et de Therapie-Cellulaire and the Groupe-Francophone des Myelodysplasies

    ... recorded in 67 patients. Donors were sibling (n = 75) or HLA -matched unrelated (10/10; n = 88). They received blood (n = 142) or ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... syndrome. Two patients had oligoclonal loss of the HLA alleles, linking immune escape to clone emergence. Two ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis.

    ... were excluded. Transplantation using T-cell depletion or HLA -mismatched or umbilical cord donors was also excluded. RIC ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes: Improved outcomes for de novo disease.

    ... IPSS score, cytogenetic abnormality, donor type, or HLA match. Larger series are needed to confirm prognostic factors so that ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Reduced intensity conditioning, combined transplantation of haploidentical hematopoietic stem cells and mesenchymal stem cells in patients with severe aplastic anemia

    ... of haploidentical HSCs and MSCs on SAA without an HLA -identical sibling donor was safe, effectively reduced the incidence of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Optimization of therapy for severe aplastic anemia based on clinical, biologic, and treatment response parameters: conclusions of an international working group on severe aplastic anemia convened by the Blood and Marrow Transplant Clinical Trials Network.

    ... donor transplantation approaches for patients lacking HLA -matched unrelated donors must be improved. A partnership of BMT, IST, ...

    Research Article last updated 07/20/2018 - 5:14pm.